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Thursday, January 26

13:00 - 13:10 Opening Remarks
13:10 - 15:30 Session1 Cancer Immunotherapy
Chairperson: Hiroshi Shiku
Cancer immunotherapy by combination of small molecules with PD-1 blockade
  Tasuku Honjo : Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University
Immuno-oncology drug combinations for cancer therapy
  Nils Lonberg : Immuno-Oncology and Biologics Discovery, Bristol-Myers Squibb
A novel combination immunotherapy targeting tumor-associated macrophages cures tumor highly resistant to immune checkpoint blockade
  Hiroshi Shiku : Department of Immuno-gene Therapy, Mie University Graduate School of Medicine, Center for Comprehensive Cancer Immunotherapy, Mie University
Role of FoxP3+ T cells in cancer immunology
  Hiroyoshi Nishikawa : Exploratory Oncology Research& Clinical Trial Center, National Cancer Center Japan
15:30 - 16:00 Coffee break
16:00 - 17:00 ‌Osamu Hayaishi Memorial Lecture 2017
Chairperson: Fumihiko Matsuda
Personalizing cancer immunotherapy
  Robert David Schreiber : Department of Pathology and Immunology, Washington University School of Medicine

Friday, January 27

9:00 - 10:50 Session2 Immune Regulation-1
Chairperson: Sidonia Fagarasan
A new look at T cell exhaustion
  Rafi Ahmed : Department of Microbiology and Immunology, Emory Vaccine Center, Emory University
Involvement of PD-1 in antibody diversification and immune homeostasis
  Sidonia Fagarasan : Laboratory for Mucosal Immunity, RIKEN Center for Integrative Medical Sciences
Tumor and host factors regulating immunotherapy efficacy
  Thomas F. Gajewski : Department of Pathology, The University of Chicago
(Short Talk) DNA repair pathway regulates PD-L1 expression in cancer cells
  Atsushi Shibata : Advanced Scientific Research Leaders Development Unit, Gunma University
10:50 - 11:10 Coffee break
11:10 - 12:40 Session3 Mutations in Cancer
Chairperson: Seishi Ogawa
Interrogating the architecture of cancer genomes
  Peter Campbell : Wellcome Trust Sanger Institute
Intersection of genome and immunological microenvironments in human hepatobiliary cancer
  Tatsuhiro Shibata : ①National Cancer Center Research Institute, National Cancer Center Japan / ②The Institute of Medical Science, The University of Tokyo
A novel genetic mechanism of evading anti-tumor immunity in multiple human cancers
  Seishi Ogawa : Department of Pathology and Tumor Biology, Kyoto University
12:40 - 13:40 Lunch
13:40 - Poster Viewing
14:40 - 16:10 Session4 B-lymphomagenesis
Chairperson: Riccardo Dalla-Favera
Molecular pathogenesis of B cell lymphoma
  Riccardo Dalla-Favera : Institute for Cancer Genetics, the Departments of Pathology and Genetics & Development, and the Herbert Irving Comprehensive Cancer Center, Columbia University
Infection and inflammation as drivers of clonal evolution of human B cell malignancies
  Markus Müschen : Department of Laboratory Medicine, UCSF, Hematopoietic Malignancies Program, UCSF Helen Diller Family Comprehensive Cancer Center
Genome instability and B cell lymphomagenesis
  Qiang Pan-Hammarström :Division of Clinical Immunology & Transfusion medicine, Department of Laboratory Medicine, Karolinska Institute
16:10 - 16:30 Coffee break
16:30 - 17:50 Session5 Immune Regulation-2
Chairperson: Fotini Nina Papavasiliou
Roles of APOBEC proteins in hepatitis B virus and human papillomavirus type 16 infections
  Masamichi Muramatsu : Department of Molecular Genetics, Graduate School of Medical Science, Kanazawa University
Adaptive fine tuning of genetic information by RNA editing and modification
  Fotini Nina Papavasiliou : Laboratory of Lymphocyte Biology, The Rockefeller University
(Short Talk) Hypoxia shifts T cell response toward Th2-type immunity
  Akio Ohta : 1 New England Inflammation and Tissue Protection Institute, Northeastern University
2 Department of Molecular Medicine, Foundation for Biomedical Research and Innovation
18:30 - Reception Reception is open to the all participants.
(free of charge)

Saturday, January 28

9:00 - 10:20 Session6 Genome Instability and Diseases-1
Chairperson: Yves Pommier
DNA repair genomic alterations and impact for precision medicine
  Yves Pommier : Center for Cancer Research, National Cancer Institute
The highly conserved proteins Topoisomerase I and Sub1 play critical roles in suppressing G4 DNA-induced genome instability
  Nayun Kim : Department of Microbiology and Moledular Genetics, University of Texas
(Short Talk) Topoisomerase 1 enrolls in diversification of Ig gene under the regulation of activation-induced cytidine deaminase (AID)
  Maki Kobayashi : Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University
10:20 - 10:40 Coffee break
10:40 - 12:30 Session7 Genome Instability and Diseases-2
Chairperson: Bernard E. Weissman
Oxidative DNA damage and repair in carcinogenesis and neurodegeneration
  Yusaku Nakabeppu : Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University
Human genetic disorders associated with deficiencies in the DNA repair system
  Tomoo Ogi : Research Institute of Environmental Medicine, Nagoya University
Therapeutic targeting of SWI/SNF complex mutations in human tumors.
  Bernard E. Weissman : Pathology and Laboratory Medicine, UNC-Chapel Hill, Cancer Genetics, University of North Carolina, School of Medicine
(Short Talk) Chromatin remodeler SMARCA4 recruits topoisomerase 1 and suppresses transcription associated genomic instability
  Afzal Husain : Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University
  Closing Remarks
14:30 - 16:00 市民公開講座(外部リンク)