The 83rd Annual Scientific Meeting of the Japanese Circulation Society

Symposium
Inflammation and Immunology in human heart disease

ENGLISH

Chairperson: Yasushi Sakata
(Division of Cardiovascular Medicine, Osaka University Graduate School of Medicine)
Inflammation of the heart primarily and secondarily causes myocardial dysfunction. The patients with advanced heart failure frequently show cardiac autoantibodies, meaning cardiac inflammation is a broad pathophysiologic mechanism.
Histological findings of endomyocardial biopsy (EMB) samples determine the Dallas criteria for the diagnosis of myocarditis. However, because of reduced sensitivity to the Dallas criteria, EMB includes some improvements like LV sampling, immunohistochemistry, molecular markers, the use of polymerase chain reaction to detect viral genomes.
Infections, drugs, and autoimmune system are thought to cause cardiac inflammation through myocyte death, cytokines, and activation of immune system. Most patients show the phenotype of acute myocarditis. However, some patients have a diagnosis of dilated cardiomyopathy with the accumulation and invasion of inflammatory cells and dissolution and necrosis of myocytes in heart tissue. These variations of phenotyping require further examinations of inflammation, immune system, and genes.
This symposium will broadly discuss inflammatory cardiomyopathy through EMB observations.

CLOSE

↑ pagetop

© 2018- The 83rd Annual Scientific Meeting of the Japanese Circulation Society. All Rights Reserved.