In the past several decades, major advances have been made on the understanding of cardiovascular diseases, and novel pharmacological agents and devices have been developed. Such advancement in the cardiovascular medicine improved strategies for prevention and treatments of cardiovascular diseases, resulting in remarkable prolongation of the life span of people, at least, in developed countries. Breakthroughs achieved by basic research on the pathobiology has made crucial contributions to drug discovery and device development for treatment of cardiovascular diseases. However, even now, pathogenesis of many diseases such as heart failure, arrhythmia, and pulmonary hypertension, has not been elucidated, and current treatments in the clinical arena are not directly targeting etiologies of the diseases. In addition, the number of elderly patients with cardiovascular diseases has been increasing, and their cardiovascular diseases are often modified by concurrent inflammatory diseases, metabolic diseases, and/or even malignant tumors. On the other hand, remarkable progress has been made in many areas of basic cardiovascular research, including methodologies for functional genomics, genome editing, epigenome analysis, induction of cellular regeneration, molecular imaging in vitro and in vivo. Novel concepts also have been emerged for mitochondrial function, cell death, cardiac metabolism and links between cell metabolism and intracellular signaling. In this session, the results of cutting edge basic research based on novel methodologies and concepts will be presented, and future perspective of basic and interdisciplinary cardiovascular research will be discussed.