It is widely accepted that organ homeostasis is regulated by intercellular and organ communication. Impairment of the systems regulating organ homeostasis contributes to pathological phenotypes associated with aging. For example, accumulation of senescent cells with age leads to impairment of tissue regeneration. Senescent cells develop the senescence-associated secretory phenotype that leads to further accumulation of senescent cells in tissues, thereby promoting organ aging. Pathological aging of certain organs disturbs the machinery involved in maintenance of whole body homeostasis, such as changes of the cardiovascular system secondary to dysregulation of the immune and metabolic systems, and this dysregulation is thought to be mediated by various neural and/or humoral factors. Impairment of cardiovascular homeostasis in turn causes pathological aging of various tissues that contributes to the onset and progression of age-associated diseases. However, we still do not fully understand how aging impairs the maintenance of homeostasis and promotes pathological aging of the cardiovascular system. At this symposium, we are expecting a number of interesting presentations about novel insights on this topic, as well as discussions about the perspectives of research on cardiovascular aging.