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The 130th Annual Meeting of the Japanese Ophthalmological Society
Program
Invited Lecture
Invited Lecture 1
Saturday, April 11, 10:35-11:35 Room 1
Genetic Risk is not your Destiny: From Susceptibility to Resilience in Age-related Macular Degeneration
Speaker
Caroline C.W. Klaver ( Erasmus MC Rotterdam and Radboudumc Nijmegen, the Netherlands / IOB and Univ. of Basel, Switzerland)
Invited Lecture 2
Friday, April 10, 10:40-11:40 Room 1
Controlling and managing the multiple faces of inflammation
Speaker
Andrew D. Dick ( UCL-Inst. of Ophthalmology, UCL / School of Cellular and Molecular Medicine, Univ. of Bristol, / NIHR Biomedical Research Ctr., Moorfields-UCL, UK)
Symposium
Symposium 1
Thursday, April 9, 9:00-10:20 Room 1
Research paving the way for the future of glaucoma management
Organizers
Megumi Honjo ( Univ. of Tokyo, Japan)
Toshihiro Inoue ( Kumamoto Univ., Japan)
Speakers
Development of Neuroprotective and Axonal Regeneration Therapies Using Modified Neurotrophic Factor Receptors
Euido Nishijima ( The Jikei Univ. / Tokyo Metropolitan Inst. of Med. Science Visual Research Project, Japan)
Targeting mechanotransducers and extracellular matrix to control IOP
Masamitsu Shimazawa ( Molecular Pharmacology, Dept. of Biofunctional Evaluation, Gifu Pharmaceutical Univ., Japan)
Oxidative stress and ocular blood flow in glaucoma
Kota Sato ( Tohoku Univ., Japan)
Decoding glaucoma pathology through RNA Modomics
Akiko Ogawa ( Faculty of Pharmacy, Tohoku Univ. / Faculty of Life Sciences, Kumamoto Univ.)
Symposium 2
Thursday, April 9, 10:40-12:00 Room 1
Revolutionary research to transform the disease concept of diabetic retinopathy
Organizers
Kiyoshi Suzuma ( Kagawa Univ., Japan)
Miho Nozaki ( Nagoya City Univ. East Med. Center, Japan)
Speakers
DR Classification Past and Future
Kotaro Tsuboi ( Aichi Med. Univ., Japan)
Beyond the glucose control for diabetic retinopathy: Focusing on lipid metabolism
Yohei Tomita ( Keio Univ., Japan)
Multifaceted Neuroprotective Strategies for Diabetic Retinal Neurodegeneration
Ayana Suzumura ( Nagoya Univ., Japan)
Is Endothelial Plasticity Still a Key Player in Diabetic Retinopathy?
Yoko Fukushima ( Osaka Univ., Japan)
Symposium 3
Thursday, April 9, 13:40-15:00 Room 1
Paradigm shift in strabismus and amblyopia
Organizers
Tetsuro Oshika ( Univ. of Tsukuba, Japan)
Takashi Negishi ( Juntendo Univ., Japan)
Speakers
Virtual Reality-Based Therapy for Pediatric Amblyopia: Current Evidence and Emerging Challenges
Yuichi Okumura ( Juntendo Univ., Japan)
AI measurement of strabismus
Eisuke Shimizu ( Keio Univ. / OUI Inc. / Yokohama Keiai Eye Cl., Japan)
3D Model of Orbital and Extraocular Muscle Dynamics: Reproducing Normal and Pathological Eye Movements
Keiko Kunimi ( Kanagawa Dent. Univ. Yokohama Clinic, Japan)
Large-Scale Primary Strabismus Screening using Smartphone-Based Digital Ruler
Haotian Lin ( Zhongshan Ophthalmic Ctr., Sun Yat-sen Univ., China)
Symposium 4
Thursday, April 9, 9:00-10:20 Room 2
Perspective on ocular circulation in eye diseases
Organizers
Teruyo Kida ( Osaka Med. and Pharm. Univ., Japan)
Yoko Fukushima ( Univ. of Osaka, Japan)
Speakers
High-Resolution Imaging of Retinal Microvasculature in BRVO Using OCT angiography and Next-Generation AOSLO
Shin Kadomoto ( Kyoto Univ., Japan)
Pathogenesis of CSC revealed by imaging analysis of vortex veins
Hideki Shiihara ( Kagoshima Univ., Japan)
The Role of Choroidal Mast Cells in Age-related Macular Degeneration
Tomohiro Niizawa ( Chiba Univ., Japan)
Neurovascular unit in different stages of diabetic retinopathy
Mizuho Mitamura ( Hokkaido Univ., Japan)
Utility of ocular blood-flow assessment stratified by visual-field defect location
Naoki Kiyota ( Tohoku Univ., Japan)
Symposium 5
Thursday, April 9, 10:40-12:00 Room 2
Corneal Disease Management with Visual Function in Focus
Organizers
Kazuno Negishi ( Keio Univ., Japan)
Shizuka Koh ( The Univ. of Osaka, Japan)
Speakers
Considering visual function in infectious keratitis
Takehiro Matsumura ( Univ. of Fukui, Japan)
Advancing visual function assessment and management in keratoconus and Fuchs endothelial corneal dystrophy
Sayo Maeno ( The Univ. of Osaka, Japan)
Visual function in bullous keratopathy, corneal dystrophy, and pterygium
Takashi Ono ( Univ. of Tokyo, Japan)
Clinical Applications of Zernike Analysis and Fourier Analysis in the Anterior Segment of the Eye
Yukari Yagi-Yaguchi ( Tokyo Dent. Coll., Ichikawa, Japan)
Symposium 6
Thursday, April 9, 13:40-15:00 Room 2
Investigation of the Molecular Mechanisms of Lens Opacification and Strategies for Its Prevention and Control
Organizers
Shinichiro Kobayakawa ( Nippon Med. School, Musashi Kosugi Hosp., Japan)
Eri Kubo ( Kanazawa Med. Univ., Japan)
Speakers
Mechanisms of Lens Opacification in Cataracts Secondary to Systemic and Ocular Diseases
Masanobu Iida ( Machida Municipal Hosp. / The Jikei Univ., Japan)
Molecular mechanisms underlying HSF4-dependent organelle degradation in the lens
Hideaki Morishita ( Kyushu Univ., Japan)
Mechanism of Posterior Capsule Opacification and Its Inhibition
Mayumi Nagata ( Dokkyo Med. Univ., Japan)
Cataract Prevention Through Inhibition of Oxidation and Glycation
Hidetoshi Ishida ( Kanazawa Med. Univ., Japan)
Symposium 7
Japanese Session
Thursday, April 9, 9:00-10:20 Room 3
Cutting-Edge Research in Other Fields
Symposium 8
Thursday, April 9, 15:20-16:40 Room 8
Shaping the Future of Pediatric Ophthalmology
Organizers
Mineo Kondo ( Mie Univ., Japan)
Chie Sotozono ( Dept. of Ophthalmology, Kyoto Prefectural Univ. of Medicine, Japan)
Speakers
Current challenges in pediatric drug development
Mitsuru Arima ( Kyushu Univ., Japan)
Pharmacological Treatments for Childhood Myopia: Current Evidence and Future Perspectives
Tae Igarashi-Yokoi ( Tokyo Metropolitan Hiroo Hosp. / Science Tokyo, Japan)
Enhanced ophthalmological care to improve cognitive functioning in hospitalised newborn infants
Osuke Iwata ( Nagoya City Univ., Japan)
Artificial Intelligence in Pediatric Ophthalmic Diseases
Yoshiyuki Kitaguchi ( The Univ. of Osaka, Japan)
Neural Plasticity Across Development and Degeneration: Implications for Ophthalmic Disease Treatment
Ryutaro Akiba ( Chiba Univ., Japan)
Symposium 9
Thursday, April 9, 9:00-10:20 Room 9
Next-Generation Approaches in Uveitis Management opened up by Personalized Medicine
Organizers
Nobuyo Yawata ( Kyushu Univ., Japan)
Kazuichi Maruyama ( The Univ. of Osaka, Japan)
Speakers
A Multidirectional Approach Using Multimodal Imaging for Precision Medicine in Uveitis
Wataru Matsumiya ( Kobe Univ., Japan)
Liquid biopsy in the personalized medicine for uveitis
Kayo Suzuki ( Hokkaido Univ., Japan)
Decoding Uveitis: Blood Analysis for Tailored Treatment Strategies
Kinya Tsubota ( Tokyo Med. Univ., Japan)
Current Status and Future Perspectives of Personalized Medicine in Uveitis
Rie Tanaka ( Univ. of Tokyo, Japan)
Symposium 10
Thursday, April 9, 13:40-15:00 Room 9
International collaboration research across Asia
Organizers
Hitomi Saito ( Univ. of Tokyo, Japan)
Keijiro Ishikawa ( Kyushu Univ., Japan)
Speakers
International collaborative research on mesenchymal stem cell-derived exosome therapy for refractory corneal diseases
Koji Kitazawa ( Kyoto Pref. Univ., Japan)
Emerging Devices for Myopia Control and Advantages of Physician-Led International Collaborative Research
Tae Igarashi-Yokoi ( Tokyo Metropolitan Hiroo Hosp. / Science Tokyo, Japan)
From Japan to the World: New Perspectives on Glaucoma Imaging
Hitomi Saito ( Univ. of Tokyo, Japan)
Hasanuddin University Collaborative Research in Ophthalmology
Andi Muhammad Ichsan ( Hasanuddin Univ., Indonesia)
International Multicenter Study of Pediatric Retinal Diseases
Wei-Chi Wu ( Chang Gung Memorial Hosp., Taiwan)
Symposium 11
Thursday, April 9, 15:20-16:40 Room 9
Advancing Rare Disease Treatment: The Future of Genome Science and Precision Medicine
Organizers
Akiko Maeda ( Kobe City Eye Hosp., Japan)
Yusuke Murakami ( Kyushu Univ., Japan)
Speakers
Identifying novel therapeutic targets for leukemia using functional genomics
Takahiro Maeda ( Kyushu Univ., Japan)
Asian Perspectives on Inherited Retinal Diseases
Hwei Wuen Chan ( Nat. Univ. of Singapore / Nat. Univ. Hosp., Singapore)
How Genomic Epidemiology Is Accelerating Innovation in Ophthalmology
Kensuke Goto ( Nagoya Univ., Japan)
Genome Surgery for Retinal Dystrophies: Successes, Challenges, and What is Next
Jason Comander ( Mass Eye and Ear, Harvard Med. School, USA)
Symposium 12
Thursday, April 9, 15:20-16:40 Room 10
Protecting Vision: The Quest for Drug Discovery
Organizers
Yasushi Kitaoka ( St. Marianna Univ., Japan)
Yasuyuki Takai ( OSADA Eye Cl., Japan)
Speakers
NAD-related metabolism in eye diseases: Pathophysiological aspects
Emi Inagaki ( Keio Univ., Japan)
Development of Calpain-Targeted Neuroprotective Therapy for Glaucoma
Satoru Tsuda ( Tohoku Univ., Japan)
Therapeutic Potential of KUS121 for Retinal Neuroprotection: From Preclinical Evidence to Clinical Development
Hanako Ikeda ( Osaka Med. and Pharm. Univ., Japan)
Drug discovery and quality design of human iPS cell-derived RPE cell products
Fumitaka Osakada ( Nagoya Univ., Japan)
Symposium 13
Friday, April 10, 9:00-10:20 Room 1
Imaging-based evaluation and reconsideration of vitrectomy for vitreoretinal diseases
Organizers
Toshio Hisatomi ( Gifu Univ., Japan)
Yuki Morizane ( Okayama Univ., Japan)
Speakers
OCT Imaging in Vitrectomy for Epiretinal Membrane and Related Disorders
Ryo Matoba ( Okayama Univ., Japan)
Retinal Reorganization After Macular Hole Surgery: Cellular-Scale Dynamics Revealed by Adaptive Optics OCT
Yuki Muraoka ( Kyoto Univ., Japan)
The retinal morphological changes after vitrectomy with ILM peeling against rhegmatogenous retinal detachment
Toshio Hisatomi ( Gifu Univ., Japan)
Imaging Evaluation in the Management of Proliferative Diabetic Retinopathy: Preoperative Assessment and Prognosis
Ayumi Ouchi ( Juntendo Univ., Japan)
Symposium 14
Japanese Session
Friday, April 10, 9:00-10:20 Room 2
<Basic Research Seminar>Current Perspectives on Inflammation and Disease
Symposium 15
Friday, April 10, 9:00-10:20 Room 3
Unmet Needs in the Diagnosis and Pathophysiological Understanding of Allergic Conjunctival Diseases
Organizers
Nobuyuki Ebihara ( Juntendo Univ., Urayasu Hosp., Japan)
Ken Fukuda ( Kochi Univ., Japan)
Speakers
The role of IL-17 activated Col14a1+ fibroblast in inflammation induced corneal opacity
Miki Onoue ( Hayashi Eye Hosp., Japan)
The role of goblet cells in allergic conjunctival diseases
Tomoaki Ando ( Juntendo Univ., Japan)
Bridging Knowledge Gaps in Multispecialty Care for Allergic Conjunctival Diseases: Toward AI-Supported Management
Dai Miyazaki ( Tottori Univ., Japan)
Unmet Therapeutic Needs and Future Prospects in Severe Allergic Conjunctival Diseases
Ken Fukuda ( Kochi Univ., Japan)
Symposium 16
Friday, April 10, 15:50-17:10 Room 9
Three-Nation Mid-term Joint Symposium 1:
Ophthalmic Telemedicine and Public Health in Asia
Organizers
Wei He (He Vision Group, China)
Koh-Hei Sonoda ( Kyushu Univ., Japan)
Speakers
The usability and acceptability of iSpector among village users
Xingru He ( He Eye Specialist Hosp. / He Univ., China)
Retinal Imaging Research as a Window into Brain Connectivity
Emi Ueda ( Kyushu Univ., Japan)
Population-Level Insights into Ophthalmic Diseases Using National Health Data
Ahnul Ha ( Jeju National Univ., Republic of Korea)
AI-Telemedicine in East Asia
Daniel Ting ( Singapore Nat. Eye Ctr., Singapore)
Symposium 17
Friday, April 10, 9:00-10:20 Room 10
Diversity in Ophthalmology
Organizers
Yoko Ozawa ( Fujita Med. Innovation Ctr., Japan)
Takenori Inomata ( Juntendo Univ., Japan)
Speakers
Thyroid Eye Disease: Diversity in Symptoms and Treatment Approaches
Ai Kozaki ( Olympia Eye Hosp., Japan)
Expanding Career Opportunities for Ophthalmologists Through the Harmony of Cure and Care
Taku Miyake ( NEXT VISION, Japan)
Mastering Niche Specialties to Sustain a Career in Ophthalmology
Mika Tanabe ( Kyushu Univ., Japan)
Tumors of the eye: Collaboration with multiple experts
Shigenobu Suzuki (

National Cancer Ctr., Japan)

Differences in Ophthalmology Postgraduate Education Between Japan and the United States
Norimitsu Ban ( Keio Univ., Japan)
Symposium 18
Japanese Session
Friday, April 10, 15:50-17:10 Room 10
Two Years After Work Style Reform for Physicians: Achieving Balance Between Quality of Care and Work Life
Symposium 19
Saturday, April 11, 9:00-10:20 Room 1
Three-Nation Mid-term Joint Symposium 2:
Collaborative Research in the Next Generation
Organizers
Hae Jung Paik ( Gachon Univ., Korea)
Sun Xinghuai ( Shanghai Med. Coll., China)
Speakers
The clinical transformation of Gene Therapy for MYOC Mutation-Induced Glaucoma
Jingxue Zhang ( Beijing Tongren Hosp., Capital Med. Univ., China)
Toward Asia-Led Myopia Research: Japan-China-Korea Collaboration and Future Directions
Saiko Matsumura ( Toho Univ., Omori, Japan)
Mitochondrial Dysfunction in Optic Neuropathy
Hae Ri Yum ( The Catholic Univ. of Korea, Korea / Univ. of California, USA)
Retinal Vein Occlusion Revisited: Old Disease, New Understanding
Han Zhang ( China Med. Univ. First Hosp., China)
 
Symposium 20
Saturday, April 11, 9:00-10:20 Room 8
AI Technologies Ophthalmologists Should Know
Organizers
Tetsuro Oshika ( Univ. of Tsukuba, Japan)
Atsuya Miki ( Aichi Med. Univ., Japan)
Speakers
The Impact of AI Technology on Clinicians
Jun Seita ( RIKEN, Japan)
Present and Future of Artificial Intelligence in Ophthalmology
Masato Akiyama ( Kyushu Univ., Japan)
Current status and introduction of the AI-driven research in retinal diseases
Ai Sajiki ( Nagoya Univ., Japan)
Data-Driven AI Framework for Glaucoma Evaluation: Toward Optimized Screening
Kei Sano ( The Jikei Univ. School of Medicine, Japan)
Symposium 21
Japanese Session
Sunday, April 12, 9:00-10:20 Room 3 B
Challenging the time with elder vision impairment
-The missions of ophthalmologists-
International Symposium
International Symposium 1
Friday, April 10, 9:00-10:20 Room 5
Current Topics in Ocular Immunology and Uveitis
Organizers
Koh-Hei Sonoda ( Kyushu Univ., Japan)
Shwu-Jiuan Sheu ( Kaohsiung Med. Univ. Hosp., Taiwan)
Speakers
Pathogenic Insights into Uveitis Using Single cell RNA sequencing and Spatial Transcriptomics
Chihiro Fukui ( Kyushu Univ., Japan)
The Role of Microglia as Local Antigen-Presenting Cells in the Pathogenesis of Autoimmune Uveitis
Shintaro Shirahama ( Univ. of Tokyo, Japan)
Regulatory B cells in uveitis
Yi-Hsing Linda Chen ( Chang Gung Memorial Hosp., Taiwan)
CMV Retinitis in non-HIV patients, an Asian perspective
Ian Wong ( Hong Kong Sanatorium and Hosp., China)
International Symposium 2
Friday, April 10, 15:50-17:10 Room 11
The Cutting Edge of Corneal Research: Bridging Bench and Bedside
Organizers
Takashi Miyai ( Univ. of Tokyo, Japan)
Takefumi Yamaguchi ( Tokyo Dent. Coll., Ichikawa, Japan)
Speakers
Changes in Redox Metabolism in FECD: From Estrogen to Melatonin Metabolism
Ula Jurkunas ( Mass Eye and Ear / Harvard Med. School, USA)
Corneal Stromal Regeneration: Stem Cells, Hydrogels, & 3D Bioprinting
Sayan Basu ( LV Prasad Eye Inst., India)
iPS cell-derived corneal epithelium for limbal stem cell deficiency
Takeshi Soma ( Osaka Univ., Japan)
Application of artificial intelligence in anterior segment diseases
Yuta Ueno ( Tsukuba Univ., Japan)
The International Crosstalk Symposium by Young Ophthalmologists
The International Crosstalk Symposium by Young Ophthalmologists
Saturday, April 11, 9:00-10:20 Room 5
Chairs
Hirokazu Sakaguchi ( Hiroshima Univ., Japan)
Kenji Kashiwagi ( Yamanashi Univ., Japan)
Speakers
Metabolomics Facilitates Diagnosis in Common Inherited Retinal Degenerations
Chu-Hsuan Huang ( Cathay General Hosp. / Nat. Tsing Hua Univ./Nat. Taiwan Univ. Hosp., Taiwan)
Silicone intubation in ENdoscopic Dacryocystorhinostomy: 11-year RCT results
Karen Kar-Wun Chan ( Prince of Wales Hosp., China)
Anatomical and Visual Outcomes of Pediatric Retinal Detachment: Study from Nepal
Sudha Ranabhat ( Nepal Eye Hosp., Nepal)
Treatment outcomes in cytomegalovirus anterior uveitis
Thanut Boonhaijaroen ( Mahidol Univ./ Siriraj Hosp., Thailand)
Proximal Location of Optic Disc Hemorrhage and Glaucoma Progression
Young In Shin ( Gachon Univ. Gil Med. Ctr., Republic of Korea)
Host-Graft Synapses Form Functional Microstructures After Stem Cell-Derived Retinal Organoid Transplantation
Ryutaro Akiba ( Chiba Univ.)
Challenges and emerging bioengineering strategies in cell-based retinal regenerative therapy
Yasuaki Iwama ( Scripps Research / Research Ctr., Kobe City Eye Hosp. / Osaka Univ., Japan)
Organoid phenotyping for pathogenesis of EYS-associated retinal dystrophy
Yuki Otsuka ( Hyogo Pref. Amagasaki General Med. Ctr.)
Silicone oil, an intraocular surgical adjuvant, induces retinal ferroptosis. Free Radic Biol Med 228 : 33-43, 2025.
Hideyuki Shimizu ( Nagoya Univ.)
Morphological Comparison of Schlemm's Canal between Primary Open-Angle Glaucoma and Exfoliation Glaucoma
Aika Tsutsui ( Shimane Univ.)
Young Ophthalmologists Committee Symposium
Young Ophthalmologists Committee Symposium
Saturday, April 11, 9:00-10:20 Room 6
This Symposium Changes Your Game!
- Visionary Young Researchers Shaping the Future with Global Strategies
Chairs
Akiko Hanyuda ( Keio Univ.)
Ryoh Funatsu ( Kagoshima Univ.)
Panelists
Nobuhiro Kato ( Kurume Univ.)
Kanae Fukutsu ( Hokkaido Univ.)
Speaker
Is Research All There Is to Life? -Seven Tips to Living Well: Meaning, Joy, and a Sustainable Medical Career-
Toru Nakano ( Osaka Univ.)
Late Breaking Symposium
Late Breaking Symposium
Friday, April 10, 15:50-17:10 Room 8
Chairs
Nobuyo Yawata ( Kyushu Univ., Japan)
Yasuo Yanagi ( Yokohama City Univ., Japan)
Speakers
Long-Term Multicenter Study and Insights on Uveitis Epidemiology in Taiwan
Yih-Shiou Hwang ( Chang Gung Memorial Hosp., Taiwan)
Microbiome and Ocular Inflammation
Rupesh Agrawal ( Nat. Healthcare Group Eye Inst., Tan Tock Seng Hosp./ Lee Kong Chian School of Medicine, Nanyang Technoligcal Univ./ Singapore Eye Research Inst., Singapore)
Corneal Neuralgia: What do we know and where are we now?
Yu-Chi Liu ( Singapore National Eye Center, Singapore)
Improved Detection of Vitreoretinal Lymphoma using Cell-Free DNA
Rajesh Rao ( Univ. of Michigan, USA)
Transforming Ophthalmological Diagnostics through Vision-Language Models
Ching-Yu Cheng ( Yong Loo Lin School of Medicine, Nat. Univ. of Singapore, Singapore)
FLQ-101 Phase 1 Retinopathy of Prematurity Trial: Current Status
Darius M. Moshfeghi ( Stanford Univ., USA)