The 74th Annual Meeting of the Japanese Society of Hematology / Program　【 October 19-21, 2012　Kyoto International Conference Center Kyoto, Japan 】

(Excerpted Version: Lectures in English)

Friday, October 19, 2012

【Special Lecture】

Aplastic anemia, telomere attrition, and the new telomeropathies

[ 11:15～12:00 ]	[ Main Hall ]
Chairperson: Keiya Ozawa (Jichi Medical University, Japan)
Speaker: Neal S. Young (NHBLI, NIH, USA)

【EHA Special Lecture】

Maintenance therapy in lymphoma

[ 11:15～12:00 ]	[ Annex 1 ]
Chairperson: Tomoki Naoe (Nagoya University, Japan)
Speaker: Ulrich Jäger (Medical University of Vienna (MUW), Austria)

【Presidential Symposium】

Innovative Gene & Cell Therapy for Hematological Diseases

[ 13:50～16:00 ]	[ Main Hall ]
Chairpersons: Keiya Ozawa (Jichi Medical University, Japan) Renier J. Brentjens (Memorial Sloan Kettering Cancer Center, USA)
Speakers:
Chimeric antigen receptor (CAR) modified T cells as a novel approach to cancer immunotherapy: Initial promising clinical responses and future directions
Renier J. Brentjens (Memorial Sloan Kettering Cancer Center, USA)
Gene therapy for hemophilia
Katherine A. High (Perelman School of Medicine at the University of Pennsylvania/Howard Hughes Medical Institute/The Children's Hospital of Philadelphia, USA)
Genome editing with engineered zinc finger nucleases
Philip D. Gregory (Sangamo BioSciences Inc, USA)
iPS cell research using large animals
Yutaka Hanazono (Jichi Medical University, Japan)

【Symposium】

The Research Front Line of Immune Thrombocytopenia

[ 9:00～11:10 ]	[ Annex 2 ]
Chairpersons: Tsukasa Ohmori (Jichi Medical University, Japan) Yutaka Yatomi (The University of Tokyo, Japan)
Speakers:
Pathophysiology and diagnosis of primary immune thrombocytopenia
Yoshiaki Tomiyama (Osaka University Hospital, Japan)
Current management of immune thrombocytopenia in Japan
Yoshitaka Miyakawa (Keio University, Japan)
Thrombopoietin mimetics for the treatment of ITP
David J. Kuter (Harvard Medical School, USA)
Chronic immune thrombocytopenia as a disease with or without association of defined diseases in children
Masatoshi Takagi (Tokyo Medical and Dental University, Japan)
Thrombocytopenia in the antiphospholipid syndrome
Ricard Cervera (Department of Autoimmune Diseases, Hospital Clinic, Spain)

Epigenomics of Hematopoiesis and Cancer

[ 9:00～11:10 ]	[ Room A ]
Chairpersons: Toru Nakano (Osaka University, Japan) Toshikazu Ushijima (National Cancer Center, Japan)
Speakers:
Role of the polycomb group proteins in the restriction of tumor development
Atsushi Iwama (Chiba University, Japan)
H3K27 methylation regulators and their roles in acute leukemia
Iannis Aifantis (NYU School of Medicine, Howard Hughes Medical Institute, USA)
Regulation of histone modifications in hematopoietic and leukemic stem cells
Issei Kitabayashi (National Cancer Center Research Institute, Japan)
Aberrant DNA methylation - Its origin and diagnostic applications
Toshikazu Ushijima (National Cancer Center, Japan)
Cancer epigenetics: New drugs and paradigms
Frank Lyko (German Cancer Research Center, Germany)

Myeloid Malignancies in a New Era of Molecularly Targeted Therapy

[ 13:50～16:00 ]	[ Room A ]
Chairpersons: Hitoshi Kiyoi (Nagoya University, Japan) Kazuo Tamura (Fukuoka University, Japan)
Speakers:
Cancer stem cell research for innovative Cell-modifying technologies
Hideshi Ishii (Osaka University, Japan)
DNA hydroxymethylation in hematologic malignancies
Mamiko Sakata -Yanagimoto (University of Tsukuba, Japan)
Novel molecularly targeted therapy targeting resistant signals
Seiji Yano (Kanazawa University, Japan)
Prognostic, predictive and therapeutic role of microRNAs in AML
Guido Marcucci (The Ohio State University Medical Center, Comprehensive Cancer Center, USA)
Role of molecular diagnostics and MRD to guide therapy in AML
Farhad Ravandi-Kashani (University of Texas-MD Anderson Cancer Center, USA)

【Educational Lecture】

Medical consequences of nuclear accidents: Chernobyl and Fukushima

[ 10:40～11:10 ]	[ Annex 1 ]
Chairperson: Shigetaka Asano (Waseda University, Japan / Professor Emeritus, The University of Tokyo, Japan)
Speaker: Robert Peter Gale (Imperial College, UK)

Saturday, October 20, 2012

【ASH Special Lecture】

Therapy with mesenchymal stromal cells: Evolving concepts of action

[ 11:15～12:00 ]	[ Annex 1 ]
Chairperson: Toshio Suda (Keio University, Japan)

Speaker: Armand Keating (Princess Margaret Hospital / The University of Toronto, Canada)

【Symposium】

Pathophysiology of Bone Marrow Failure Syndromes
(JSH-EHA Joint Symposium)

[ 9:00～11:10 ]	[ Annex 1 ]
Chairpersons: Hideki Nakakuma (Wakayama Medical University, Japan) Mario Cazzola (University of Pavia, Italy)
Speakers:
Preferential activation of hematopoietic stem cells with genetic alterations in patients with acquired aplastic anemia
Shinji Nakao (Kanazawa University, Japan)
The molecular basis of myelodysplastic syndromes and its clinical relevance
Mario Cazzola (University of Pavia, Italy)
Similarities and differences between hypoplastic refractory cytopenia and aplastic anemia in children
Seiji Kojima (Nagoya University, Japan)
The pathophysiology of PNH: Lessons from targeted therapy
Peter Hillmen (St. James's Institute of Oncology, UK)

Mesenchymal Stem Cells: Progress Toward Clinical Application for Hematopoietic Stem Cell Transplantation

[ 9:00～11:10 ]	[ Room A ]
Chairpersons: Taira Maekawa (Kyoto University, Japan) Tomohiro Morio (Tokyo Medical and Dental University, Japan)
Speakers:
Clinical development of MSC for the treatment of steroid refractory acute GVHD in Japan
Katsuhiko Tachibana (JCR Pharmaceuticals Co., Ltd., Japan)
Mesenchymal stem cells for treatment of Graft-Versus-Host Disease
Katarina Le Blanc (Laboratory Medicine, Herm, Karolinska Institutet, Swden)
Regulation of hematopoiesis by mesenchymal stem cells
Yasuo Miura (Kyoto University Hospital, Japan)
Mesenchymal stem cells expand the spectrum of cell therapy
Edwin M. Horwitz (The University of Pennsylvania Perelman School of Medicine, USA)
Mesenchymal stem cell-based therapy -bench to bed-
Akihiro Umezawa (National Center for Child Health and Development, Japan)

Science-Based Medicine for Malignant Lymphoma
(JSH-ASH Joint Symposium)

[ 14:45～16:55 ]	[ Main Hall ]
Chairpersons: Wyndham Wilson (National Cancer Institute, USA) Kensei Tobinai (National Cancer Center Hospital, Japan)
Speakers:
Molecular pathogenesis of B-cell lymphoma
Riccardo Dalla-Favera (Columbia University, USA)
Molecular characterization of T/NK cell malignancies
Masao Seto (Aichi Cancer Center Research Institute, Japan)
Diffuse large B-cell lymphoma: Treatment decisions based on molecular features
Wyndham Wilson (National Cancer Institute, USA)
Science-based management of adult T-cell leukemia-lymphoma
Kunihiro Tsukasaki (Nagasaki University Hospital, Japan)

【Educational Lecture】

Bioimaging of stem cell functions in wound healing and tumor development

[ 14:45～15:15 ]	[ Annex 2 ]
Chairperson: Hiroshi Shiku (Mie University, Japan)
Speaker: Frank Marini (Wake Forest Institute for Regenerative Medicine, Wake Forest Comprehensive Cancer Center, USA)

Recent progress in hematopoietic stem cell gene therapy

[ 15:15～15:45 ]	[ Annex 2 ]
Chairperson: Kenzaburo Tani (Medical Institute of Bioregulation, Kyushu University, Japan)
Speaker: Fabio Candotti (Bethesda, MD, USA)

Sunday, October 21, 2012

【Asian Joint Symposium】

Acute Leukemia: Pathophysiology and Development of Novel Treatments

[ 9:00～11:10 ]	[ Room D ]
Chairpersons: Kaiyan Liu (Peking University People's Hospital, China) Shigeru Chiba (Tsukuba University, Japan)
Speakers:
Prognostic relevance of recurrent mutations in adult acute myeloid leukemia
Chirayu Udomsakdi Auewarakul (Mahidol University, Thailand)
A mouse model bearing "conventional" knock-in of Npm1 mutation reveals myeloid expansion and implies a perturbation in hematopoietic microenvironment
Wen-Chien Chou (National Taiwan University Hospital and Fu-Jen University, Taiwan)
Targeting chemotherapy-resistant AML stem cells
Fumihiko Ishikawa (RIKEN Research Center for Allergy and Immunology, Japan)
Immunotherapy utilizing haploidentical HCT and subsequent donor NK cell infusion in refractory acute leukemia
Kyoo-Hyung Lee (University of Ulsan, Asan Medical Center, Korea)
Allogeneic hematopoietic stem cell transplantation in China: Where we are and where to go
Xiao-jun Huang (Peking University People's Hospital, China)

【Symposium】

Multiple Myeloma: Topics in Basic Science Applicable to the Development of Novel Therapies

[ 9:00～11:10 ]	[ Main Hall ]
Chairpersons: Masahiro Kizaki (Saitama Medical Center, Saitama Medical University, Japan) Shinsuke Iida (Nagoya City University, Japan)
Speakers:
Origin of the myeloma initiating cells and development of its targeting therapies
Naoki Hosen (Osaka University, Japan)
Intracellular targets of Immunomodulatory derivatives of thalidomide (IMiD^®)
Suzanne Lentzsch (Columbia University, USA)
How to overcome the cell adhesion-mediated drug resistance in multiple myeloma
Yusuke Furukawa (Jichi Medical University, Japan)
Targeting the interplay between myeloma cells and the bone marrow microenvironment
Masahiro Abe (University of Tokushima, Japan)
Targeting myeloma cells and their marrow microenvironment
Kenneth C. Anderson (Jerome Lipper Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, USA)