Atherosclerotic cardiovascular disease (ASCVD) such as myocardial infarction or stroke have been increasing and become a leading cause of death or loss of healthy life in an aging society. Although the importance of management of traditional risk factors such as LDL-cholesterol, diabetes or hypertension has been established, we cannot fully suppress the incidence of ASCVD until now. Novel strategies in managing and preventing atherosclerosis are desired.
Next generation sequencing based technologies for genomics, transcriptomics, and epigenomics are now increasingly focused on the characterization of individual cells
These single-cell analyses allow researchers to uncover new and potentially unexpected biological discoveries relative to traditional profiling methods that assess bulk populations. Single-cell RNA sequencing (scRNA-seq), for example, can reveal complex and rare cell populations and track the trajectories of distinct cell lineages in development.
These novel technologies enable us to assess complex immune systems leading the formation of atherosclerosis. For example, the heterogeneous component of immune cells in atherosclerosis has been revealed by scRNA-seq. Clonal hematopoiesis in bone marrow was reported to affect the formation of atherosclerosis. A new antigen for atherosclerosis ‘ALDH4A1’ was discovered by a single cell repertoire analysis. We would like to discuss novel progresses targeting immune systems in a research field of atherosclerosis in this symposium.