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SCIENTIFIC PROGRAM

Click here for Program at a Glance

CONGRESS ABSTRACTS have been published as a supplement of the international online journal, ACER (Alcoholism: Clinical and Experimental Research) in the Wiley Online Library since August 30, 2018 at https://onlinelibrary.wiley.com/toc/15300277/2018/42/S2.

Plenary Speakers

Plenary Lecture 1

Vladimir Poznyak

Monday, September 10, 9:00-9:45

Alcohol policy development and research:
A complex interface

Vladimir Poznyak
Department of Mental Health and Substance Abuse, World Health Organization, Geneva, Switzerland

Vladimir Poznyak is a Coordinator of Management of Substance Abuse unit at the World Health Organization (WHO) in Geneva, and in this capacity he is responsible for coordination of normative, advocacy, research and country support activities on alcohol, drugs and addictive behaviors in WHO headquarters. A medical doctor and psychiatrist by professional background, Dr Poznyak received his PhD from All-Union Center of Medical and Biological Problems of Addiction Medicine in Moscow, Russian Federation, and his research at that time was focused on gender differences in alcohol dependence. Dr Poznyak has been at the forefront of the WHO Secretariat’s work on development and implementation of the WHO Global strategy to reduce the harmful use of alcohol and on addressing public health dimensions of the world drug problem. In recent years Dr Poznyak coordinated the work on 11th revision of the International Classification of Diseases (ICD) for disorders due to substance use and addictive behaviors.

Psychoactive, toxic and dependence-producing properties of alcohol are well documented, and recent research findings expand the list of health conditions with causal relationship to alcohol consumption. In spite of around 3 million deaths attributable worldwide to alcohol every year and around 250 million people affected by alcohol use disorders, effective alcohol control policies lack strong support in many societies and jurisdictions. The WHO Global strategy to reduce the harmful use of alcohol is the only global non-binding policy framework on alcohol that was negotiated and agreed at the intergovernmental level. The recent global policy developments, including Sustainable Development Goals 2030 with special health target on substance abuse and strategies for prevention and control of Noncommunicable Diseases (NCDs) create new opportunities for effective alcohol control. Research findings on effectiveness and cost-effectiveness of policy options prompted development of “best buy” concept that includes feasible policies and interventions with an average cost-effectiveness ration of ≤ 1$ 100/DALY. For reducing the harmful use of alcohol these policy options include increase in excise taxes and prices of alcoholic beverages, reduction in physical availability of retailed alcohol and comprehensive restrictions or bans on alcohol advertising. Screening and brief interventions (SBI) for hazardous and harmful drinking has good cost-effectiveness ratio, but their implementation in health systems is limited. The 11th revision of the International Classification of Diseases, released in June 2018, is expected to facilitate implementation of alcohol-focused interventions in health services. The global data on implementation of alcohol policy options indicate that research efforts do not necessarily translate into science-based policy developments, and factors influencing the complex interface between research and alcohol policy development will be discussed in the presentation.

Plenary Lecture 2

Markus A. Heilig

Tuesday, September 11, 8:15-9:00

ISBRA Tabakoff Award Lecture
Developing neuroscience based treatments for alcohol addiction - Challenges and prospects

Markus A. Heilig
Center for Social and Affective Neuroscience, Sweden

Markus Heilig received his MD and PhD from Lund University, Sweden, 1986 and 1989, resp, and was a post-doc at The Scripps Research Institute, LaJolla, CA 1990 - 1992. Upon returning to Sweden and completing clinical training in psychiatry, he served at the Karolinska Institute, Stockholm, Sweden, in various clinical and academic leadership capacities until 2004. Between 2004 – 2015, he was the chief of intramural clinical and translational research at the US National Inst on Alcohol Abuse and Alcoholism. In 2015, he was recruited back to Sweden as the founding director of the Center for Social and Affective Neuroscience at Linköping Univ, in a joint initiative of the Swedish Research Council, the University and the Region.

Heilig's research is centered on regulation of negative effect, as it applies to affective, anxiety and addictive disorders. He has published more than 250 peer reviewed papers, including in leading journals such as Science, Lancet, PNAS and others. His work has been cited >10000 times, resulting in an H-index of about 60. Current efforts in the Heilig lab are focused on identifying novel mechanisms for pharmacotherapy of addiction, and developing these from preclinical target discovery and validation to early human proof-of-concept trials. Currently pursued targets include systems involved in stress- and negative effect such as neurokinins, nociceptin, glutamate and cannabinoids. Recently, his laboratory has expanded the scope of its research incorporate the neurobiology of choosing between alcohol and natural rewards, and how social factors influence these behaviors.

Neurobiological research on addictive disorders has grown exponentially in the past two decades. It has also become increasingly sophisticated in its ability to identify neural circuits and molecular mechanisms behind drug seeking and taking. These advances have fueled hopes that novel, neuroscience based treatments would emerge and transform treatment of alcohol addiction. That hope has not yet materialized. Existing medications for alcohol addiction provide proof-of-principle for pharmacological treatment of this disorder, but their discovery precedes the neuroscience revolution, and they have not been adopted broadly enough to transform clinical practice.
This talk will review the ups, downs and new ups over two decades of translational work attempting to identify and target novel mechanisms for treatment of alcohol addiction. The first theme will discuss the limitations of focusing on brain reward mechanisms as therapeutic targets, and review our work on reprogramming of the transcriptome within key brain structures as a mechanism behind long-term neuroadaptations that fundamentally change the incentives behind alcohol seeking. The second theme will discuss the limitations of studying drug seeking in isolation. It will introduce the critical importance of studying alcohol seeking in the context of availability of natural rewards, and of individual vulnerability. Implications for medications development will be discussed.

Plenary Lecture 3

Jurgen Rehm

Tuesday, September 11, 9:00-9:45

Burden of disease caused by alcohol and alcohol use disorders – What do we know and where do we go?

Jurgen Rehm
Centre for Addiction and Mental Health, Toronto, Canada

Jürgen Rehm, Ph.D., has been appointed the Inaugural Chair for Addiction Policy at the Dalla Lana School of Public Health of the University of Toronto (Canada). In addition, he holds positions at the Centre for Addiction and Mental Health as Senior Director of the Institute for Mental Health Policy Research, and at the Institute for Clinical Psychology and Psychotherapy of the Technical University Dresden (Germany). Dr. Rehm has published more than 900 peer-reviewed journal articles in substance use research; and is listed among the Thompson Reuters/Clarivate most highly cited in his field (top 1% with respect to impact as measured by citations). He has been awarded the Jellinek and the European Addiction Research Awards.

Alcohol use has long been known to be a major risk factor for burden of disease and injury. The newest global and regional estimates of alcohol-attributable burden of disease as measured in deaths, years of life lost and disability adjusted life years will be presented, with emphasis on alcohol-attributable infectious disease, gastrointestinal disease and injuries.

The contribution of heavy drinking occasions and liver disease in the etiology of alcohol-attributable disease burden will be highlighted, as well as the interaction with between alcohol use and socioeconomic status and poverty. As a specific example of the latter, we will highlight the contribution of alcohol to the current stagnation of life expectancy in the USA.

Plenary Lecture 4

Yoshiyuki Takei

Tuesday, September 11, 13:50-14:35

Liver parenchymal cells and sinusoidal cells: Cell sociology in alcoholic liver disease

Yoshiyuki Takei
Department of Gastroenterology, Mie University School of Medicine, Japan

Yoshiyuki Takei, MD, PhD is Vice President of Mie University and Professor and Chairman of the Department of Gastroenterology, Mie University Graduate School of Medicine. Following his training as a hepatology specialist at the First Department of Medicine, Osaka University and the University of North Carolina at Chapel Hill (mentor: Late Prof. Ronald G Thurman), his translational and clinical investigations have focused on alcoholic liver disease and non-alcoholic fatty liver disease with special interest in the interaction and crosstalk between hepatocytes and non-parenchymal cells. He has published more than 300 peer-reviewed articles in respected international journals.
He is a long-time member of the ISBRA and was the Vice Chairman of the Local Organizing Committee of the ISBRA Congress in 2012. He has also served on the boards of the ISBRA and the Japan Society of Hepatology.

Since the direct hepatotoxicity of ethanol was demonstrated by Charles Lieber almost half a century ago, significant progress has been made in research on the mechanism of alcohol liver disease (ALD). Consequently, the mechanism of ALD is considered to be diverse and multifaceted. In the late 1980s, it was proposed that alcohol is not only the direct toxicant to liver parenchymal cells, but also targets a variety of liver sinusoidal cells including Kupffer cells, stellate cells and sinusoidal endothelial cells (SECs). This hypothesis led to the general theory that alcohol-induced liver damage is a result of multiple, complex parallel processes. Ethanol-induced factors that communicate stress signals between hepatocytes and non-parenchymal cells initiate and perpetuate the pathological processes responsible for liver damage and disease progression to alcoholic hepatitis and cirrhosis. For example, at high concentrations, ethanol evokes endothelin-1 expression in SECs and causes contraction of the hepatic sinusoid leading to disturbed hepatic microcirculation. Moreover, ethanol increases gut-derived endotoxins (pathogen-associated molecular patterns), leading to the activation of Kupffer cells, culminating in the overproduction of toxic mediators such as tumor necrosis factor-α. Thus, interaction and crosstalk between hepatocytes and non-parenchymal cells appear to be crucial to the pathogenesis of ALD.

Plenary Lecture 5

Reinout W. Wiers

Wednesday, September 12, 9:00-9:45

On the Use of Cognitive Training in the Treatment of Alcohol Use Disorders

Reinout W. Wiers
Professor of Developmental Psychopathology, Addiction Development and Psychopathology (ADAPT) Lab; Chair of Developmental Psychology, Faculteitshoogleraar FMG UvA; and Department of Psychology, Universiteit van Amsterdam, the Netherlands

Professor Reinout W. Wiers is professor of developmental psychopathology and distinguished faculty professor at the University of Amsterdam (UvA). He is senior editor of the journal Addiction, and on the editorial board of several other journals of addiction and clinical psychology. Wiers is internationally known for his work on implicit cognition and addiction. He received the prestigious VIDI (2002) and VICI (2008) research grants from the Dutch National Science Foundation (N.W.O.), for research on assessing and changing implicit cognitive processes in addiction. He also received several other grants from national and international funding agencies. His 2011 Psychological Science paper on changing the approach-bias for alcohol in alcohol-dependent papers with clinical effects is in the top 1% of most cited papers of that year in psychology and psychiatry. Wiers published over 250 international papers and book chapters, and his current Hirsch-index is 45 (web of science) or 65, google scholar, see: https://scholar.google.nl/citations?user=2vKDTuoAAAAJ&hl=nl

Alcohol Use Disorders (AUDs) are typically treated with psychosocial treatments and/or medication. However, there is a third category of interventions to consider: varieties of Cognitive Training (CT). Two types of CT can be distinguished: those in which general abilities are trained (e.g. working memory training) and those in which initial motivational reactions to alcohol are targeted, so called cognitive biases (Cognitive Bias Modification, CBM). I will review the state of affairs in both. Training of general abilities takes a long time, but does show promise for a subgroup of patients. CBM has shown to increase one-year abstinence in several large clinical trials, with effect sizes similar to medication for alcohol (NNT=12). It is also becoming clear for which individuals CBM shows most promise as an add-on treatment (those with a strong cue-reactivity and/or impulsivity), and we are beginning to understand the neurocognitive mechanisms underlying training effects (e.g., reduced cue-reactivity). CT shows modest but reliable effects as add-on to regular psychosocial treatment, but does not appear to work in the absence of psychosocial treatment, nor in the absence of motivation to change (e.g. in proof-of-principle studies in students). Finally, I will sketch ways forward, such as combining training with neurostimulation.

Plenary Lecture 6

Vijay A. Ramchandani

Wednesday, September 12, 13:50-14:35

Alcohol Pharmacodynamics and Neurofunctional Domains underlying Alcohol Use Disorder

Vijay A. Ramchandani
Section on Human Psychopharmacology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA

Vijay Ramchandani, Ph.D., is a Clinical Investigator and Chief of the Section on Human Psychopharmacology in the intramural research program of the National Institute on Alcohol Abuse and Alcoholism, one of the National Institutes of Health, in Bethesda, MD. Dr. Ramchandani obtained his undergraduate degree in Pharmaceutical Sciences from Bombay University in India in 1990, and his Ph.D. in Pharmaceutical Sciences from Virginia Commonwealth University, Richmond, VA in 1996. From 1996 to 2002, he worked at the Alcohol Research Center at Indiana University School of Medicine, Indianapolis, IN, first as a Research Associate and then as an Assistant Scientist and Part-time Assistant Professor. In 2003, Dr. Ramchandani joined NIAAA as a Staff Scientist in the Laboratory of Clinical and Translational Studies, and started his independent research program in 2010. Dr. Ramchandani also serves as the Deputy Training Director for the NIAAA intramural program.
Dr. Ramchandani’s research is focused on characterizing the clinical pharmacology of alcohol in humans using behavioral, neuroendocrine, psychophysiological and functional imaging measures, and the relationship between alcohol response and risk factors, both genetic and environmental, for alcohol use disorders. He is also conducting studies to develop human laboratory paradigms to screen novel potential pharmacotherapies for alcohol use disorders, in terms of their ability to alter the motivation, consumption and pharmacodynamics of alcohol in high-risk drinkers.

Alcohol use disorder has a tremendous negative individual and global impact, and there is an urgent need to understand its etiology as well as to advance treatment for this devastating illness. Research on the clinical pharmacology of alcohol is necessary to explain how variability in alcohol response affects the risk of developing this disorder. Furthermore, an improved understanding of the genetic, environmental, and neurobiological factors that affect alcohol response could lead to the development of novel treatments.
Dr. Ramchandani’s presentation will focus on research advances in characterization of the pharmacological effects of alcohol in humans across the neurofunctional domains of incentive salience, negative affect, and executive dysfunction that are critical to the cycle of addiction. He will include examples of his own human laboratory research that utilizes novel intravenous alcohol administration paradigms to provide a platform of highly controlled alcohol exposure, combined with a range of pharmacodynamic measures, in individuals across the spectrum of alcohol consumption and risk. These studies provide important insights into the relationship between alcohol pharmacodynamics and risk of alcohol problems, and facilitate the identification and screening of potential targets for treatment of alcohol use disorder.

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Symposium

Symposium 1

Sunday, September 9, 13:30-15:00 Room A

ISBRA-APSAAR Symposium: Alcohol and the Behavioural Addictions - Part 1: Alcohol and Gambling Disorder

Organizer / Chair:
Sawitri Assanangkornchai
  Prince of Songkla University, Thailand
Chair:
John B. Saunders Centre for Youth Substance Abuse Research, University of Queensland, Australia
SY1-1
ALCOHOL AND BEHAVIOURAL ADDICTIONS: AN OVERVIEW
Max W. Abbott
National Institute of Public Health and Mental Health Research, Auckland University of Technology, New Zealand
SY1-2
PREVALENCE AND CORRELATES OF THE BEHAVIOURAL ADDICTIONS
Hans Jürgen Rumpf
Department of Psychiatry and Psychotherapy, University of Lübeck, Germany
SY1-3
DIAGNOSIS AND CLASSIFICATION OF THE BEHAVIOURAL ADDICTIONS IN ICD-11
John B. Saunders
Centre for Youth Substance Abuse Research, University of Queensland, Australia
SY1-4
PREVALENCE OF GAMBLING AND GAMING DISORDERS IN ASIAN COUNTRIES
Phunnapa Kittirattanapaiboon
Department of Mental Health, Ministry of Public Health, Thailand
DISCUSSANT:
John B. Saunders Centre for Youth Substance Abuse Research, University of Queensland, Australia

Symposium 2

Sunday, September 9, 15:30-17:00 Room A

ISBRA-APSAAR Symposium: Alcohol and the Behavioural Addictions - Part 2: Gaming Disorder: Diagnosis and Management

Organizer / Chair:
Sawitri Assanangkornchai
  Prince of Songkla University, Thailand
Chair:
John B. Saunders Centre for Youth Substance Abuse Research, University of Queensland, Australia
SY2-1
TECHNIQUES FOR SCREENING AND ASSESSMENT FOR GAMING DISORDER
Phunnapa Kittirattanapaiboon
Department of Mental Health, Ministry of Public Health, Thailand
SY2-2
ASSESSMENT AND MANAGEMENT OF GAMING AND ONLINE GAMBLING DISORDER IN YOUNG ADULTS IN INDONESIA
Kristiana Siste Kurniasanti
Department of Psychiatry, University of Indonesia, Indonesia
SY2-3
MANAGEMENT OF GAMING DISORDER AND INTERNET ADDICTION IN JAPAN
Satoko Mihara
National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY2-4
GOVERNMENT POLICIES AND PROGRAMS TO MINIMIZE THE HARM FROM GAMING DISORDER
Sang Kyu Lee
Psychiatry, Hallym University, Chuncheon Sacred Heart Hospital, Korea
DISCUSSANT:
Karl F. Mann Central Institute of Mental Health, University of Heidelberg, Germany

Symposium 3

Sunday, September 9, 13:30-15:00 Room B-2

Risk Factors for Alcoholic Liver Disease

Organizer / Chair:
Helmut K. Seitz Centre of Alcohol Research University of Heidelberg, Germany
Chair:
Manuela G. Neuman University of Toronto, Canada
SY3-1
GENETICS AS RISK FACTORS IN ALCOHOLIC LIVER CIRRHOSIS (ALC)
Devanshi Seth
Royal Prince Alfred Hospital and Centenary Institute, Australia
SY3-2
THE INTERPLAY OF ALCOHOL WITH DRUGS INCLUDES MULTIPLE FACETS
Manuela Neuman
University of Toronto, Canada
SY3-3
HEPATIC SINUSOIDAL PRESSURE AS PROGRESSION FACTOR FOR ALCOHOLIC LIVER DISEASE: DOES SPLEEN STIFFNESS ALLOW TO ALLOCATE THE HISTOLOGICAL SIDE OF PRESSURE ELEVATION?
Omar Elshaarawy
Centre of Alcohol Research University of Heidelberg, Germany
SY3-4
CYTOCHROME P450 (CYP2E1) AS A RISK FACTOR FOR ALCOHOLIC LIVER DISEASE (ALD)
Helmut K. Seitz
Centre of Alcohol Research University of Heidelberg, Germany

Symposium 4

Sunday, September 9, 15:30-17:00 Room B-2

Cellular and Extracellular Effects of Alcohol Exposure in Liver and Extrahepatic Organs

Organizer / Chair:
Carol A. Casey Department of Internal Medicine, University of Nebraska Medical Center and Omaha VAMC, USA
Chair:
Terrence M. Donohue Dept. of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
SY4-1
ETHANOL ADMINISTRATION INCREASES POLYUBIQUITYLATION OF HEPATIC LIPID DROPLET MEMBRANE PROTEINS
Paul G. Thomes
University of Nebraska Medical Center, USA
SY4-2
TRANSCRIPTION FACTOR EB (TFEB) AND LIPOPHAGY ARE DISRUPTED BY ETHANOL FEEDING AND NORMALIZED AFTER ETHANOL WITHDRAWAL
Terrence M. Donohue
Dept. of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
SY4-3
UPREGULATED AUTOPHAGY IN SERTOLI CELLS OF ETHANOL-TREATED RATS: EVIDENCES, MECHANISMS AND IMPLICATIONS
Nabil Eid
Anatomy and Cell Biology Department, Division of Life Sciences, Osaka Medical College, Takatsuki, Osaka, Japan
SY4-4
ROLE OF SPLICING REGULATOR SLU7 IN ETHANOL-INDUCED INFLAMMATION AND LIVER INJURY
Min You
Department of Pharmaceutical Sciences, Northeast Ohio Medical University, USA
SY4-5
MIF INHIBITION PROTECTS HEPATOCYTES FROM GAO-BINGE- INDUCED INJURY INDEPENDENT OF NEUTROPHIL ACCUMULATION
Laura Nagy
Cleveland Clinic, USA

Symposium 5

Sunday, September 9, 13:30-15:00 Room K

Direct Alcohol Modulation of Ion Channels: Insights and Enigmas in the Post-structure Era

Organizer / Chair:
Rebecca J. Howard Department of Biochemistry & Biophysics, Stockholm University, Sweden
Chair:
R Adron Harris Waggoner Center for Alcohol & Addiction Research, The University of Texas at Austin, USA
SY5-1
DETERMINING THE IN VIVO IMPORTANCE AND ACTION OF ETHANOL ON THE BK POTASSIUM CHANNEL
Jon Pierce
University of Texas at Austin, USA
SY5-2
DUAL ACTIVATION OF NEURONAL G PROTEIN-GATED INWARDLY RECTIFYINGPOTASSIUM (GIRK) CHANNELS BY CHOLESTEROL AND ALCOHOL
Paul A. Slesinger
Dept. of Neuroscience, Icahn School of Medicine at Mount Sinai, USA
SY5-3
CLUSTERS OF HYDROPHOBIC AMINO ACIDS IN THE MEMBRANE-ASSOCIATED DOMAINS REGULATE ION CHANNEL GATING AND FORM PUTATIVE SITES OF ALCOHOL ACTION IN THE NMDA RECEPTOR
Robert W. Peoples
Department of Biomedical Sciences, Marquette University, USA
SY5-4
ALCOHOL MODULATION VIA ALLOSTERIC TRANSMEMBRANE SITES IN PENTAMERIC LIGAND-GATED ION CHANNELS
Rebecca J. Howard
Department of Biochemistry & Biophysics, Stockholm University, Sweden

Symposium 6

Sunday, September 9, 15:30-17:00 Room K

Genetic and Epigenetic Signatures That Mediate Differential Alcohol Drinking and Ethanol Responses

Organizer / Chair:
Kristin Hamre Dept. of Anat. & Neurobiol., Univ. of Tennessee Health Science Center, USA
Chair:
Feng C. Zhou Indiana University School of Medicine, USA
INTRODUCTION TO THE SYMPOSIUM:
Kristin Hamre Dept. of Anat. & Neurobiol., Univ. of Tennessee Health Science Center, USA
SY6-1
GENOMIC SIGNATURE OF ALCOHOL PREFERRING (P) AND NON-PREFERRING (NP) RATS
Feng C. Zhou
Indiana University School of Medicine, USA
SY6-2
GENETIC POLYMORPHISMS OF ADH1B AND ALDH2 AND THEIR PHENOTYPES IN JAPANESE ALCOHOLIC MEN
Akira Yokoyama
National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY6-3
TRANSCRIPTIONAL REGULATION OF LINE-1 RETROTRANSPOSONS IN MODELS OF ALCOHOL USE DISORDER
Igor Ponomarev
Waggoner Center for Alcohol & Addiction Research and the College of Pharmacy, The University of Texas at Austin, USA
SY6-4
EPIGENETIC DYSREGULATION IN THE MPFC REGULATES ALCOHOL-ASSOCIATED BEHAVIORS
Estelle Barbier
Center for Social Affective Neuroscience, IKE, Linkoping University, Sweden
DISCUSSANT:
Feng C. Zhou Indiana University School of Medicine, USA

Symposium 7

Sunday, September 9, 13:30-15:00 Room J

Possibilities and Challenges Using e-Health and m-Health for Addiction Treatment

Organizer / Chair:
Ayumi Takano Department of Psychiatric Nursing, Yokohama City University, Japan
Chair:
Toshiaki Baba Department of Mental Health Policy, National Institute of Mental Health, Japan
SY7-1
HOW EFFECTIVE IS A BRIEF WEBSITE INTERVENTION WITH PERSONALIZED NORMATIVE FEEDBACK AMONG JAPANESE ADULTS WITH RISKY DRINKING? FINDINGS FROM A PILOT RCT
Toshitaka Hamamura
Division of Clinical Psychology, Department of Integrated Educational Sciences, The University of Tokyo, Japan
SY7-2
M-HEALTH INTERVENTIONS FOR GAMBLING PROBLEMS
Ryuhei So
Okayama Psychiatric Medical Center, Japan
SY7-3
SMARTPHONE-BASED SELF-MONITORING APPLICATION FOR DRUG USERS: CO-PRODUCTION WITH TARGETED USERS
Ayumi Takano
Department of Psychiatric Nursing, Yokohama City University, Japan
SY7-4
POLICY IMPLICATIONS OF EHEALTH INTERVENTIONS FOR ADDICTION
Toshiaki Baba
Department of Mental Health Policy, National Institute of Mental Health, Japan

Symposium 8

Sunday, September 9, 15:30-17:00 Room J

Perspectives of Occupational Therapy in Addiction

Organizer:
Tetsutaro Kosago National Hospital Organization Kurihama Medical and Addiction Center, Japan
Chair:
Hitoshi Maesato National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY8-1
ADDICTION BEHAVIOUR AS AN OCCUPATION
Yoshitaka Sato
Okayama Psychiatric Medical Center, Japan
SY8-2
OCCUPATION-FOCUSED INTERVENTION FOR RECOVERY FROM ADDICTION
Takeshi Misawa
National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY8-3
THE COLLABORATIVE POTENTIAL OF OCCUPATIONAL THERAPY IN SUBSTANCE ADDICTION AND REHABILITATION
Michael P. Sy
Tokyo Metropolitan University, Japan
SY8-4
OCCUPATIONAL THERAPY TO MEET THE NEEDS OF ALCOHOL DEPENDENCE CLIENTS
Tetsutaro Kosago
National Hospital Organization Kurihama Medical and Addiction Center, Japan

Symposium 9

Sunday, September 9, 13:30-15:00 Room C-1

Gambling and Gaming Disorder

Organizer / Chair:
Hannu Alho Clinicum, University of Helsinki, Helsinki, Finland
Chair:
Susumu Higuchi National Hospital Organization Kurihama Medical and Addiction Center, Japan
INTRODUCTION TO THE SYMPOSIUM:
Hannu Alho Clinicum, University of Helsinki, Helsinki, Finland
SY9-1
TREATING GAMBLING DISORDER WITH FAST ACTING OPIOID ANTAGONIST - NALOXONE NASAL SPRAY: A NOVEL FEASIBILITY STUDY
Hannu Alho
Clinicum, University of Helsinki, Helsinki, Finland
SY9-2
TEMPERAMENT AND CHARACTER PROFILE IN PATHOLOGICAL GAMBLING: A COMPARISON WITH ALCOHOL DEPENDENCE
Changwoo Han
Department of Psychiatry, Gangnam Eulji Hospital, Eulji University, Seoul, Korea
SY9-3
PRESENT SITUATION OF GAMBLING AND PREVALENCE OF GAMBLING DISORDERS IN JAPAN
Sachio Matsushita
National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY9-4
CLINICAL CHARACTERISTICS OF TREATMENT SEEKING INDIVIDUALS WITH GAMBLING DISORDER IN JAPAN: A SYSTEMATIC COMPARISON OF DIAGNOSTIC CRITERIA IN ICD-11 AND DSM-5
Takanobu Matsuzaki
National Hospital Organization Kurihama Medical and Addiction Center, Japan

Symposium 10

Sunday, September 9, 15:30-17:00 Room C-1

Recent Findings Regarding Internet Addiction and Gaming Disorder

Organizer:
Hideki Nakayama National Hospital Organization Kurihama Medical and Addiction Center, Japan
Chair:
Dai-jin Kim Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea
SY10-1
PRECISION MEDICINE IN BEHAVIOR ADDICTION
Dai-jin Kim
Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea
SY10-2
THE ROLE OF MOTIVES IN ADDICTIVE VIDEO GAMING
Jöel Billieux
University of Luxembourg, Luxembourg
SY10-3
THE COHORT STUDY ON GAMING DISORDER: THE INTERNET USER COHORT FOR UNBIASED RECOGNITION OF GAMING DISORDER IN EARLY ADOLESCENCE (ICURE) STUDY
Sun-jin Jo
Dept. Preventive Medicine, College of Medicine, The Catholic University of Korea, Korea
SY10-4
SCREENING AND INTERVENTION NEEDS FOR INTERNET ADDICTION COMORBID WITH NEURODEVELOPMENTAL DISORDERS
Ryuhei So
Okayama Psychiatric Medical Center, Japan
SY10-5
EFFECTIVENESS OF A SCHOOL-BASED BRIEF GROUP INTERVENTION FOR THE PREVENTION OF INTERNET ADDICTION
Hideki Nakayama
National Hospital Organization Kurihama Medical and Addiction Center, Japan

Symposium 11

Monday, September 10, 9:50-11:20 Room A

Role and Therapeutic Potential of Oxytocin in Alcohol Addiction

Organizer / Chair:
Howard C. Becker Medical University of South Carolina, USA
Chair:
Rosana Camarini University of Sao Paulo, Brazil
SY11-1
ROLE OF OXYTOCIN IN THE MODULATING EFFECTS OF ENVIRONMENTAL ENRICHMENT ON ALCOHOL-RELATED BEHAVIORS IN MICE
Rosana Camarini
University of Sao Paulo, Brazil
SY11-2
ROLE OF OXYTOCIN IN ALCOHOL SELF-ADMINISTRATION AND STRESS-INDUCED RELAPSE-LIKE BEHAVIOR IN MICE
Howard C. Becker
Medical University of South Carolina, USA
SY11-3
DEVELOPMENT OF SMALL MOLECULE OXYTOCIN LIGANDS FOR ALCOHOL DEPENDENCE AND DRUG ADDICTION
Iain S. Mcgregor
University of Sydney, Australia
SY11-4
THE OXYTOCIN SYSTEM IN ALCOHOLISM: CONVERGENT EVIDENCE FROM HUMANS AND RATS
Rainer Spanagel
Institute for Psychopharmacology, Central Institute of Mental Health Mannheim, Uniklinikum Mannheim, University of Heidelberg, Germany
DISCUSSANT:
Leandro F. Vendruscolo National Institute on Drug Abuse, USA

Symposium 12

Monday, September 10, 13:00-14:30 Room A

ISBRA-JSPH Symposium: Prevention of Health Problems Due to Inadequate Alcohol Drinking -Viewpoints from Community Total Health

Chairs:
Tomonori Okamura Department of Preventive Medicine and Public Health, Keio University School of Medicine, Japan
Hideyuki Kanda Department of Environmental Medicine and Public Health, Shimane University, Japan
SY12-1
CANCER RISK AND ALCOHOL: GENE-ENVIRONMENT INTERACTION AMONG ASIAN
Keitaro Matsuo
Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Japan
SY12-2
ALCOHOL AND CARDIOVASCULAR DISEASE, ITS RISK FACTORS, AND OTHER HEALTH DISORDERS IN THE COMMUNITY
Aya Higashiyama
National Cerebral and Cardiovascular Center, Japan
SY12-3
ALCOHOL AND MINORS IN JAPAN
Hideyuki Kanda
Department of Environmental Medicine and Public Health, Shimane University, Japan
SY12-4
ALCOHOL-RELATED PROBLEMS IN JAPANESE PRIMARY CARE
Hisashi Yoshimoto
Department of Family Medicine, General Practice and Community Health, Faculty of Medicine, University of Tsukuba, Japan
SY12-5
PUBLIC HEALTH POLICY ON HARMFUL HEALTH HAZARDS OF ALCOHOL USE IN JAPAN: THE POPULATION STRATEGY PERSPECTIVE
Yoneatsu Osaki
Division of Environmental and Preventive Medicine, Department of Social Medicine, Faculty of Medicine, Tottori University, Japan

Symposium 13

Monday, September 10, 14:50-16:10 Room A

International Comparison of Measures against Alcohol-related Harm - In Reference to Japanese Basic Act - Part 1

Organizer:
Aro Ino Kasumigaura Clinic, Japan
Organizer / Chair:
Naoyuki Hironaka Dept. Pharmacology, LSI Medience Corp., Japan
Chair:
Megumi Goto Psychiatry & Behavioral Sciences, Tokyo Medical and Dental University, Japan
SY13-1
JAPANESE BASIC ACT ON MEASURES AGAINST ALCOHOL-RELATED HARM: FORMATION, SIGNIFICANCE, AND FUTURE
Aro Ino
Kasumigaura Clinic, Japan
SY13-2
PROCESS OF FORMULATING THE BASIC LAW AND ITS SIGNIFICANCE FOR INTERNAL MEDICINE AND GENERAL PRACTICE / FAMILY MEDICINE
Hisashi Yoshimoto
Department of Family Medicine, General Practice and Community Health, Faculty of Medicine, University of Tsukuba, Japan
SY13-3
HISTORY OF PSYCHIATRIC TREATMENT FOR ALCOHOL USE DISORDER AND THE IMPACT OF BASIC ACT FOR MEASURES AGAINST ALCOHOL-RELATED HEALTH HARM IN JAPAN
Chie Iwahara
National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY13-4
ESSENTIAL ELEMENTS OF EFFECTIVE ALCOHOL POLICIES AND THEIR IMPLEMENTATION IN THE WORLD
Vladimir Poznyak
Department of Mental Health and Substance Abuse, World Health Organization, Geneva, Switzerland

Symposium 14

Monday, September 10, 16:20-18:00 Room A

International Comparison of Measures against Alcohol-related Harm - In Reference to Japanese Basic Act - Part 2

Organizer:
Aro Ino Kasumigaura Clinic, Japan
Organizer / Chair:
Naoyuki Hironaka Dept. Pharmacology, LSI Medience Corp., Japan
Chair:
Megumi Goto Psychiatry & Behavioral Sciences, Tokyo Medical and Dental University, Japan
SY14-1
THE HISTORY OF ALCOHOL RESEARCH IN THE UNITED STATES AND THE NIAAA
Kenneth R. Warren
National Institute on Alcohol Abuse and Alcoholism, USA
SY14-2
ALCOHOL POLICIES IN THE USA IN RELATION TO THE JAPANESE BASIC LAW: WHAT WE CAN LEARN FROM EACH OTHER
Thomas F. Babor
Department of Community Medicine, University of Connecticut School of Medicine, USA
SY14-3
PUBLIC HEALTH MEASURES AGAINST ALCOHOL-RELATED PROBLEMS IN THAILAND
Sawitri Assanangkornchai
Prince of Songkla University, Thailand
SY14-4
ALCOHOL POLICIES IN UK, FOCUSING ON EARLY HARM PREVENTION
Irene Guerrini
South London & Maudsley NHS Foundation Trust, UK

Symposium 15

Monday, September 10, 9:50-11:20 Room B-2

CIFASD Studies on the Genetics of FASD

Organizer / Chair:
Edward Riley San Diego State University, USA
SY15-1
IDENTIFYING GENETIC MODIFIERS OF SUSCEPTIBILITY TO PRENATAL ALCOHOL EXPOSURE IN MICE
Scott E. Parnell
Bowles Center for Alcohol Sudies, University of North Carolina, USA
SY15-2
SYNERGISTIC GENE-ENVIRONMENT INTERACTIONS IN A ZEBRAFISH MODEL OF FETAL ALCOHOL SPECTRUM DISORDERS
Johann K. Eberhart
Department of Molecular Biosciences, University of Texas at Austin, USA
SY15-3
CREATION OF AN ONLINE COLLABORATIVE INITIATIVE ON FETAL ALCOHOL SPECTRUM DISORDERS (CIFASD) REGISTRY FOR THE STUDY OF THE GENETICS OF FASD
Tatiana M. Foroud
Department of Medical and Molecular Genetics, Indiana University School of Medicine, USA
DISCUSSANT:
Edward Riley San Diego State University, USA

Symposium 16

Monday, September 10, 13:00-14:30 Room B-2

Mechanisms of Multi-organ Injury by Alcohol and HIV-1 Interactions Through the Gut-liver-brain Axis

Organizer / Chair:
B. J. Song National Institute on Alcohol Abuse and Alcoholism, Laboratory of Membrane Biochemistry and Biophysics, Rockville, Maryland, USA
Chair:
Mohammed Akbar National Institute on Alcohol Abuse and Alcoholism, Laboratory of Membrane Biochemistry and Biophysics, Rockville, Maryland, USA
SY16-1
MECHANISMS OF MULTI-ORGAN INJURY BY ALCOHOL AND HIV-1 INTERACTIONS THROUGH THE GUT-LIVER-BRAIN AXIS
Ali Keshavarzian
Rush University Medical Center, Department of Internal Medicine, Chicago, Illinois, USA
SY16-2
ROLE OF CYP2E1 IN PROTEIN MODIFICATIONS AND GUT LEAKINESS, LEADING TO LIVER INFLAMMATION AND BRAIN INJURY IN HIV-1 TRANSGENIC RATS
B.J. Song
National Institute on Alcohol Abuse and Alcoholism, Laboratory of Membrane Biochemistry and Biophysics, Rockville, Maryland, USA
SY16-3
ALCOHOL AND HIV ASSOCIATED CHANGES IN THE GUT-LIVER-BRAIN AXIS: RELEVANCE TO HEPATIC INJURY AND NEUROINFLAMMATION
Shirish Barve
Department of Medicine, University of Louisville Medical School, Louisville, Kentucky, USA
SY16-4
INTERPLAY BETWEEN NEUROHIV AND BINGE EXPOSURE TO ALCOHOL
Sulie Chang
Institute of Neuroimmune Pharmacology and Department of Biological Sciences, Seton Hall University, South Orange, New Jersey, USA
SY16-5
HOW HIV-1 INFECTION AND ALCOHOL LEAD TO NEURODEGENERATION: MECHANISMS AND INTERVENTIONS
Yuri Persidsky
Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
DISCUSSANT:
Kendall J. Bryant National Institutes of Health, USA

Symposium 17

Monday, September 10, 14:50-16:20 Room B-2

Building a Global Alcohol Research Agenda for Reproductive and Child Health: Closing Interdisciplinary Gaps to Address the Needs of People Affected by HIV/ AIDS - Part 1

Organizer / Chair:
Tatiana N. Balachova University of Oklahoma Health Sciences Center, USA
Chair:
Niranjan Saggurti Population Council, India
SY17-1
ALCOHOL USE AND ADVERSE HEALTH OUTCOMES FOR YOUNG HIV-INFECTED RUSSIAN WOMEN: ASSOCIATION BETWEEN PHOSPHATIDYLETHANOL AS A NOVEL BIOMARKER OF ALCOHOL CONSUMPTION, SEXUAL RISK, OTHER SUBSTANCE USE, AND ANTIRETROVIRAL MEDICATION ADHERENCE
Ralph J. Diclemente
Department of Socio-behavioral Sciences, College of Global Public Health, New York University, USA
SY17-2
ALCOHOL USE BY WOMEN LIVING WITH HIV (WLWH) IN UGANDA AND SOUTH AFRICA DURING PERICONCEPTION AND PREGNANCY PERIODS IS HIGH
Lynn T. Matthews
Massachusetts General Hospital / Harvard Medical School, USA
SY17-3
ALCOHOL USE AMONG HIV-INFECTED PREGNANT WOMEN AND CHILD OUTCOMES IN THE PEDIATRIC HIV AIDS COHORT STUDY (PHACS)
Denise Jacobson
Department of Epidemiology, Harvard T. H. Chan School of Public Health, USA
SY17-4
ALCOHOL USE, PREGNANCY PLANNING, AND REPRODUCTIVE HEALTH CONCERNS IN PEOPLE LIVING WITH HIV/AIDS IN RUSSIA
Anait Y. Marianian
Federal State Public Scientific Institution (SC FHHRP), Russia
DISCUSSANT:
BUILDING A GLOBAL ALCOHOL RESEARCH AGENDA FOR REPRODUCTIVE AND CHILD HEALTH
Denise A. Russo National Institutes of Health, EKS National Institute of Child Health and Human Development, USA

Symposium 18

Monday, September 10, 16:30-18:00 Room B-2

Building a Global Alcohol Research Agenda for Reproductive and Child Health: Closing Interdisciplinary Gaps to Address the Needs of People Affected by HIV/ AIDS - Part 2

Organizer / Chair:
Tatiana N. Balachova University of Oklahoma Health Sciences Center, USA
Chair:
Niranjan Saggurti Population Council, India
SY18-1
ROLE OF ALCOHOL ABUSE, HIV-1 INFECTION AND VAGINAL MICROBIAL DYSBIOSIS IN THE REPRODUCTIVE HEALTH OF WOMEN
Shirish Barve
Department of Medicine, University of Louisville, USA
SY18-2
ALCOHOL PHARMACOTHERAPIES TO IMPROVE ALCOHOL AND HIV TREATMENT OUTCOMES AFTER RELEASE FROM PRISON FOR WOMEN LIVING WITH HIV AND ALCOHOL USE DISORDERS IN THE UNITED STATES CRIMINAL JUSTICE SYSTEM
Sandra A. Springer
Department of Internal Medicine, Section of Infectious Disease, Yale School of Medicine, USA
SY18-3
ALCOHOL USE AND GENITAL TRACT INFECTIONS IN INDIA: LESSONS LEARNED FROM RESEARCH, COMMUNITY IMPLEMENTATION, AND BUILDING NATIONAL CAPACITY
Niranjan Saggurti
Population Council, India
DISCUSSANT:
DISCUSSION ON ALCOHOL AND HIV RESEARCH FOR REPRODUCTIVE HEALTH: CLOSING GAPS BETWEEN DISCIPLINES AND SETTING RESEARCH AGENDA
Kendall J. Bryant National Institutes of Health, USA

Symposium 19

Monday, September 10, 9:50-11:20 Room K

Mechanisms of Compulsive Aversion-resistant Alcohol Drinking in Rodents

Organizer / Chair:
Stephen L. Boehm Department of Psychology, Indiana University - Purdue University Indianapolis, USA
SY19-1
AVERSION- (QUININE-) RESISTANT ALCOHOL DRINKING IN MOUSE LINES GENETICALLYSELECTED FOR HIGH AND LOW ALCOHOL PREFERENCE DRINKING
Nicholas J. Grahame
Department of Psychology, Indiana University - Purdue University Indianapolis, USA
SY19-2
NEUROBIOLOGICAL MECHANISMS UNDERLYING LOSS OF CONTROL OVER ALCOHOL USE IN RATS
Heidi Lesscher
Department of Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Netherlands
SY19-3
COMPULSIVE RESPONDING FOR ALCOHOL IS MORE AUTOMATIC AND MOTIVATED: INSIGHTS INTO OVERLAP OF COMPULSION AND HABIT CIRCUITRY
Frederic W. Hopf
University of California San Francisco, USA
SY19-4
COMPULSIVE ALCOHOL SEEKING IS ASSOCIATED WITH AN INABILITY TO DISENGAGE DORSOLATERAL-DOPAMINE DEPENDENT CONTROL OVER BEHAVIOUR
Chiara Giuliano
University of Cambridge, Department of Psychology, UK

Symposium 20

Monday, September 10, 13:00-14:30 Room K

To Be or Not to Be: Transcription and Translation Mechanisms Underlying Alcohol Use Disorders

Organizer / Chair:
Dorit Ron Dept. of Neurology UCSF, USA
SY20-1
MTORC1 IN THE ORBITOFRONTAL CORTEX CONTROLS ALCOHOL SEEKING AND HABIT
Dorit Ron
Dept. of Neurology, UCSF, USA
SY20-2
COMMON MECHANISMS BETWEEN ETHANOL AND RAPIDLY ACTING ANTIDEPRESSANTS
Kimberly Raab-Graham
Wake Forest Translational Alcohol Research Center, Physiology and Pharmacology, Wake Forest School of Medicine, USA
SY20-3
GENOME-WIDE TRANSCRIPTIONAL CHANGES IN THE RAT HIPPOCAMPUS DURING WITHDRAWAL FROM CHRONIC ALCOHOL DRINKING IDENTIFIES ALTERED NEUROIMMUNE SIGNALING
Amy W. Lasek
Psychiatry, University of Illinois at Chicago, USA
SY20-4
MOLECULAR BASIS OF FOR CHOOSING ALCOHOL OVER A NATURAL REWARD
Markus A. Heilig
Center for Social and Affective Neuroscience, Sweden
DISCUSSANT:
Antonio Noronha Dept. of Neurology UCSF, USA

Symposium 21

Monday, September 10, 14:50-16:20 Room K

Systems Biology for Analysis of Complex Traits Including Alcoholism (the NFPCDD Symposium)

Organizer / Chair:
Boris Tabakoff Skaggs School of Pharmacy & Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, USA
Chair:
Paula L. Hoffman Department of Pharmacology, School of Medicine, University of Colorado Denver, USA
SY21-1
THE NFPCDD SYMPOSIUM ON SYSTEMS BIOLOGY FOR ANALYSIS OF COMPLEX TRAITS INCLUDING ALCOHOLISM
Boris Tabakoff
Skaggs School of Pharmacy & Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, USA
SY21-2
SYSTEMS-GENETICS TO COMPLEX DISEASES: FROM GENE NETWORKS TO DRUGGABLE TARGETS
Enrico G. Petretto
Duke-NUS Medical School, Singapore
SY21-3
USING MULTI-OMICS DATA TO DETERMINE CAUSALITY AND CONSEQUENCES FOR PATHOLOGICAL TRAITS IN ANIMALS AND HUMANS
Mete Civelek
Department of Biomedical Engineering, University of Virginia, USA
SY21-4
THE QUANTITATIVE "OMICS" ANALYSIS OF COMPLEX ALCOHOL-RELATED TRAITS IN THE HYBRID RAT DIVERSITY PANEL
Laura M. Saba
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, USA

Symposium 22

Monday, September 10, 16:30-18:00 Room K

Promising Targets of Alcohol Addiction

Organizer / Chair:
A Leslie Morrow Psychiatry and Pharmacology, UNC School of Medicine, USA
SY22-1
PRECLINICAL EVALUATION OF NEW HDAC INHIBITORS IN ANIMAL MODELS OF ALCOHOL USE DISORDERS
Mickael Naassila
Université de Picardie Jules Verne - INSERM UMR 1247 - GRAP; Amiens, France
SY22-2
TRANSGENIC RAT LINES FOR REGION SPECIFIC INTERFERENCE WITH TARGET GENE EXPRESSION: EFFECT ON ALCOHOL-SEEKING BEHAVIOR
Wolfgang H. Sommer
(Rainer Spanagel)
Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
SY22-3
ALPHA-1 BLOCKADE AS PERSONALIZED TREATMENTS FOR ALCOHOL USE DISORDER
Carolina L. Haass-Koffler
Brown University, USA
SY22-4
ENDOGENOUS NEUROSTEROID ALLOPREGNANOLONE INHIBITS TOLL-LIKE-4 RECEPTOR SIGNALING TO TARGET ALCOHOL ADDICTION
A Leslie Morrow
Psychiatry and Pharmacology, UNC School of Medicine, USA

Symposium 23

Monday, September 10, 13:00-14:30 Room J

Chronic Alcohol Induces Plasticity in Striatal and Limbic Circuits

Organizer / Chair:
Nicholas W. Gilpin LSU Health Sciences Center – New Orleans, USA
SY23-1
DRUG-INDUCED DYSFUNCTION IN DORSOMEDIAL STRIATUM AND IN DECISION-MAKING
Bernard W. Balleine
UNSW Sydney, Australia
SY23-2
PREFRONTAL CONTROL OVER COMPULSIVE-LIKE ETHANOL-SEEKING
Andrew Holmes
NIAAA, USA
SY23-3
ALCOHOL DEPENDENCE IMPACTS VENTRAL TEGMENTAL AREA PROJECTIONS TO CENTRAL AMYGDALA
Elizabeth M. Avegno
Department of Physiology, Louisiana State University Health Sciences Center, USA
SY23-4
DISRUPTION OF BLA-NAC CIRCUITRY LEADS TO ALTERATIONS IN ETHANOL SELF-ADMINISTRATION AND AFFECTIVE BEHAVIORS
Sarah Ewin
Wake Forest School of Medicine, NC, USA

Symposium 24

Monday, September 10, 14:50-16:20 Room J

Alcohol & Opioids: Intersecting Mechanisms and Treatment Opportunities for Pain Management and Addiction

Organizer / Chair:
Scott Edwards LSU Health Sciences Center New Orleans, USA
Chair:
Marcin Wojnar Department of Psychiatry, Medical University of Warsaw, Poland
SY24-1
ANOTHER IMPORTANT PIECE IN A COMPLEX PUZZLE? EXPLORING SIGNIFICANCE OF PAIN IN ALCOHOL DEPENDENCE
Marcin Wojnar
Department of Psychiatry, Medical University of Warsaw, Poland
SY24-2
OPIOID USE AND PAIN: MECHANISMS OF HEAVY DRINKING RELAPSE AMONG PATIENTS WITH ALCOHOL DEPENDENCE
Katie Witkiewitz
University of New Mexico, USA
SY24-3
GLUCOCORTICOID-MEDIATED PLASTICITY UNDERLIES NEGATIVE EMOTIONAL STATES AND COMPULSIVE ALCOHOL AND OPIOID USE
Stephanie A. Carmack
Intramural Research Program, National Institute on Drug Abuse, USA
SY24-4
CENTRAL AMYGDALA CIRCUITS MEDIATE HYPERALGESIA IN ALCOHOL-DEPENDENT RATS
Nicholas W. Gilpin
LSU Health Sciences Center - New Orleans, USA

Symposium 25

Monday, September 10, 16:30-18:00 Room J

Alcohol and Organ Damage: Bridging the Gap Between Bench and Bedside - Part 1: Translational

Organizer / Chair:
Kenichi Ikejima Department of Gastroenterology, Juntendo Univeristy Graduate School of Medicine, Japan
Chair:
Gavin E. Arteel Dept of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, USA
SY25-1
HEPATOCYTE-DERIVED EXTRACELLULAR VESICLES CONTAIN MICRORNA BARCODE TO CONTROL A UNIQUE TRANSCRIPTOME PROFILE OF ACTIVATED STELLATE CELLS IN ALCOHOLIC HEPATITIS
Akiko Eguchi
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Japan
SY25-2
MECHANISMS OF HEPATOCELLULAR FAILURE IN ALCOHOLIC HEPATITIS
Josepmaria Argemi
Department of Medicine, Division of Gastroenterology Hepatology and Nutrition, University of Pittsburgh, USA
SY25-3
MICROBIOTA AND LIVER DISEASE
Bernd Schnabl
Medcine, UC San Diego, USA,
SY25-4
PREVENTIVE EFFECTS OF L-CARNITINE ON HIGH-FAT DIETINDUCED STEATOHEPATITIS IN OBESE AND DIABETIC MICE
Kazuyoshi Kon
Department of Gastroenterology, Juntendo University School of Medicine, Japan

Symposium 26

Monday, September 10, 9:50-11:20 Room C-1

Binge Behaviors: Etiological Models and Underlying Psychological Factors

Organizer / Chair:
Joel Billieux University of Luxembourg, Luxembourg
SY26-1
BINGE DRINKING - A BEHAVIORAL AND ELECTROPHYSIOLOGICAL APPROACH
Pierre Maurage
Psychological Science Research Institute, Université Catholique de Louvain, Belgium
SY26-2
BINGE-WATCHING ENGAGEMENT AS DETERMINED BY MOTIVATIONS, IMPULSIVITY AND EMOTIONAL REACTIVITY: A CLUSTER ANALYTIC APPROACH
Maèva Flayelle
University of Luxembourg, Luxembourg
SY26-3
INVESTIGATING FOOD CHOICE PROCESSES USING HAND MOVEMENTS IN BULIMIA NERVOSA AND BINGE EATING DISORDER
Zoé Van Dyck
University of Luxembourg, Luxembourg

Symposium 27

Monday, September 10, 14:50-16:20 Room C-1

Long-term Consequences of Heavy Drinking in Japan, Germany and U.S

Organizer:
Michie N. Hesselbrock Department of Psychiatry, University of Connecticut School of Medicine, USA
Chairs:
Susumu Higuchi National Hospital Organization Kurihama Medical and Addiction Center, Japan
Victor M. Hesselbrock Department of Psychiatry, University of Connecticut School of Medicine, USA
SY27-1
LIVER STIFFNESS PRIOR AND AFTER ALCOHOL DETOXIFICATION AS A NOVEL PROGNOSTIC MARKER IN HEAVY DRINKERS: FIRST DATA FROM A PROSPECTIVE COHORT
Sebastian Mueller
Salem Medical Center and Center for Alcohol Research, University of Heidelberg, Germany
SY27-2
THE EFFECT OF SMOKING ON THE TREATMENT OUTCOME OF ALCOHOLIC PATIENTS WHO RECEIVED INPATIENT CBT
Mitsuru Kimura
National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY27-3
A 40 YEAR STUDY OF HEAVY DRINKING OUTCOMES IN HIGHLY EDUCATED MEN
Marc A. Schuckit
Department of Psychiatry, University of California, San Diego, USA
SY27-4
LONGTERM OUTCOMES IN ADULTS WITH ALCOHOL DEPENDENCE RE-ASSESSED AFTER AN AVERAGE OF 17 YEARS
Kathleen K. Bucholz
Psychiatry, Washington U. School of Medicine, USA
OVERALL SUMMARY:
Frederic Blow University of Michigan Medical Center, USA

Symposium 28

Monday, September 10, 16:30-18:00 Room C-1

The Current Situation of Internet Gaming Disorder from the Standpoint of Young Researchers

Organizer / Chair:
Yoko Nishitani Dept. of Forensic Medicine, Kumamoto University, Japan
Chair:
Tomohiro Shirasaka Department of Psychiatry, Teine Keijinkai Hospital, Japan
SY28-1
INTERNET GAMING DISORDER IN CHILDREN AND ADOLESCENTS: AN UPDATED LITERATURE REVIEW
Nagisa Sugaya
Unit of Public Health and Preventive Medicine, School of Medicine, Yokohama City University, Japan
SY28-2
A REPORT ON A TREATMENT PROGRAM FOR INTERNET GAMING DISORDER AMONG SOUTH KOREAN YOUTH
Jangrae Kim
Department of Addiction Psychiatry, National Center for Mental Health, an affiliate of the Ministry of Health and Welfare, Korea
SY28-3
SPOTLIGHTS ON INTERNET GAMING DISORDER AMONG UNIVERSITY STUDENTS IN EGYPT
Hussien Elkholy
Neurology and Psychiatry Department, Faculty of Medicine, Ain Shams University, Egypt
SY28-4
GAMING DEVICE USAGE PATTERNS AND INTERNET GAMING DISORDER AMONG YOUNG ADULTS IN SOUTH KOREA
Soo-hyun Paik
Addiction Center, Keyo Hospital, Korea
SY28-5
CLINICAL CHARACTERISTICS OF SOCIAL WITHDRAWAL (HIKIKOMORI) AND PROBLEMATIC INTERNET USE IN JAPAN
Tomohiro Shirasaka
Department of Psychiatry, Teine Keijinkai Hospital, Japan

Symposium 29

Tuesday, September 11, 9:55-11:25 Room A

Transgenic Animal and Pharmacological Studies of Alcohol Metabolites, from Peripheral Organs to Brain

Organizer:
Bin Gao National Institute on Alcohol Abuse and Alcoholism, NIH, USA
Chairs:
Katherine Jung Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, USA
Li Zhang National Institute on Alcohol Abuse and Alcoholism, NIH, USA
INTRODUCTION TO THE SYMPOSIUM:
Katherine Jung Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, USA
SY29-1
GENETIC DELETION OF ALDH2 EXACERBATES ALCOHOL AND CCL4-INDUCED LIVER INFLAMMATION AND FIBROSIS
Hyo-jung Kwon
College of Veterinary Medicine, Chung-Nam National University, Korea
SY29-2
ALDH2 AND OBESITY CARDIOMYOPATHY
Jun Ren
University of Wyoming, USA
SY29-3
ALDH2 SUPPRESSES CIRRHOSIS/FIBROSIS AND ALCOHOL-INDUCED HEPATOCELLULAR CARCINOMA VIA THE INHIBITION OF ACETALDEHYDE-DERIVED DNA DAMAGE AND MULTIPLE ONCOGENIC SIGNALING PATHWAYS
Bin Gao
NIAAA, NIH, USA
SY29-4
PERINATAL AND INFANTILE DEVELOPMENT: CRITICAL STAGES FOR THE ANALYSIS OF ACETALDEHYDE´S MOTIVATIONAL PROPERTIES IN HETEROGENOUS RATS
Juan C. Molina
Instituto de Investigacion Medica Mercedes y Martin Ferreyra, Argentina
SY29-5
CELL-TYPE SPECIFIC DISTRIBUTION OF BRAIN ALDH2 AND ITS CONTRIBUTION TO CANNABIS AND ETHANOL-INDUCED SYNERGISTIC EFFECTS ON PSYCHOMOTOR IMPAIRMENT
Li Zhang
National Institute on Alcohol Abuse and Alcoholism, NIH, USA
DISCUSSANT:
Helmut K. Seitz Centre of Alcohol Research University of Heidelberg, Germany

Symposium 30

Tuesday, September 11, 14:55-16:25 Room A

Novel Findings from Bench to Bedside - Glutamate Hypothesis for Addictive Disorder
Co-sponsored by Eisai Co., Ltd.

Chair:
Hidehiko Takahashi Department of Psychiatry, Kyoto University Graduate School of Medicine, Japan
SY30-1
THE ROLE OF GLUTAMATE ACTIVITY AT AMPA RECEPTORS IN ADDICTIVE DISORDER
Takuya Takahashi
Department of Physiology, Yokohama City University School of Medicine, Japan
SY30-2
ANTI-CRAVING DRUG AND THE STRUCTURE OF CRAVING
Hisatsugu Miyata
Department of Psychiatry, Jikei University School Medicine, Japan

Symposium 31

Tuesday, September 11, 16:30-18:00 Room A

Common and Different Mechanisms Underlying Dependence on Alcohol and Other Addictive Substances

Organizer / Chair:
Kazutaka Ikeda Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Japan
Chair:
Michie N. Hesselbrock Department of Psychiatry, University of Connecticut School of Medicine, USA
SY31-1
CAN WE UNTANGLE ALCOHOL AND COMORBID SUBSTANCE DEPENDENCE?
Victor M. Hesselbrock
Dept. of Psychiatry, University of Connecticut School of Medicine, USA
SY31-2
TELOMERE SHORTENING IN PATIENTS WITH ALCOHOL OR OTHER ADDICTIVE SUBSTANCES DEPENDENCE
Ming-chyi Huang
Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taiwan
SY31-3
PREFERENCE FOR ALCOHOL WITHOUT DEPENDENCE RISK: COMPARISON WITH OTHER ADDICTIVE SUBSTANCES
Hisatsugu Miyata
Department of Psychiatry, Jikei University School of Medicine, Japan
SY31-4
GIRK CHANNELS AS COMMON EFFECTORS IN SOME PATHWAYS OF ALCOHOL AND OTHER ADDICTIVE SUBSTANCES
Kazutaka Ikeda
Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Japan

Symposium 32

Tuesday, September 11, 9:55-11:25 Room B-1

Diverse Roles of Non-protein-coding RNAs: Alcohol-mediated Neuroinflammation, Regulation of Neural Stem Cell Renewal, and Epigenetic Regulation in Early Onset and Chronic Alcohol Use Disorders

Organizer / Chair:
R. Dayne Mayfield Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, USA
SY32-1
CHRONIC ALCOHOL-INDUCED MICRORNA-155 CONTRIBUTES TO NEUROINFLAMMATION IN A TLR4- DEPENDENT MANNER IN MICE
Gyongyi Szabo
University of Massachusetts Medical School, USA
SY32-2
A NOVEL PSEUDOGENE-ENCODED LONG NONCODING RNA MEDIATES FETAL ALCOHOL EFFECTS
Rajesh C. Miranda
Dept. of Neuroscience, Texas A&M University College of Medicine, USA
SY32-3
BDNF-AS IS A NOVEL LNCRNA THAT IS AN EPIGENETIC REGULATOR IN EARLY ONSET ALCOHOL USE DISORDERS
John P. Bohnsack
Department of Psychiatry, Alcohol Research Center on Epigenetics, University of Illinois at Chicago, USA
SY32-4
NOVEL LONG NON-CODING RNAS INVOLVED IN ALCOHOL USE DISORDER
Sean P. Farris
The University of Texas at Austin, USA
DISCUSSANT:
Jillian J. Kril Sydney Medical School, University of Sydney, Australia

Symposium 33

Tuesday, September 11, 14:55-16:25 Room B-1

Emerging Role of Epigenetic Processes in the Development of Alcohol Use Disorders

Organizer / Chair:
Subhash C. Pandey Center for Alcohol Research In Epigenetics, Dept. of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago IL 60612, USA
Chair:
Antonio Noronha NIH-NIAAA, Bethesda MD, USA
INTRODUCTION TO THE SYMPOSIUM:
Antonio Noronha Dept. of Neurology UCSF, USA
SY33-1
LONG-LASTING EPIGENETIC MARK OF ALCOHOL HAS A DEVELOPMENTAL WINDOW
Dipak K. Sarkar
Endocrine Program, Rutgers University, USA
SY33-2
EPIGENETIC REPROGRAMMING REGULATES ENHANCER RNA AND ADULT PSYCHOPATHOLOGY AFTER ADOLESCENT ALCOHOL EXPOSURE
Subhash C. Pandey
Center for Alcohol Research In Epigenetics, Dept. of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago IL 60612, USA
SY33-3
METHYLATION PROFILES DURING ACUTE ALCOHOL WITHDRAWAL IN A CLINICAL SAMPLE
Stephanie H. Witt
Department of Genetic Epidemiology in Psychiatry, CIMH Mannheim/Heidelberg University, Mannheim, Germany
SY33-4
ROLE OF HDAC IN BINGE DRINKING LIKE ETHANOL EXPOSURE-INDUCED ALTERATIONS IN ANXIETY, MEMORY AND SYNAPTIC PLASTICITY DURING ADOLESCENCE IN RATS
Mickael Naassila
Université de Picardie Jules Verne - UMR INSERM U1247 - GRAP, Amiens, France
DISCUSSANT:
Dipak K. Sarkar Endocrine Program, Rutgers University, USA

Symposium 34

Tuesday, September 11, 16:30-18:00 Room B-1

A Role for the Insular Cortex in Alcohol Use Disorders?

Organizer / Chair:
Angelo Bifone Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Italy
SY34-1
INTRODUCTION TO THE POTENTIAL ROLE OF THE INSULAR CORTEX IN AUD
Frederic W. Hopf
University of California San Francisco, USA
SY34-2
RESTING STATE FUNCTIONAL CONNECTIVITY OF THE INSULAR CORTEX IN RECENTLY DETOXIFIED ALCOHOLICS
Angelo Bifone
Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Italy
SY34-3
REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) OF THE INSULA FOR TREATMENT OF ALCOHOL ADDICTION
Irene Perini
Centre for Social and Affective Neuroscience, Sweden
SY34-4
CHEMOGENETIC INTERROGATION OF THE ROLE OF INSULA IN ALCOHOL CONSUMPTION
Petri Hyytiä
Department of Pharmacology, University of Helsinki, Finland
SY34-5
ALTERED INSULAR CORTEX CONNECTIVITY IN ALCOHOL POST-DEPENDENT RATS AND NORMALIZATION BY A D3 RECEPTOR SELECTIVE ANTAGONIST
Giulia Scuppa
Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy
DISCUSSANT:
Frederic W. Hopf University of California San Francisco, USA

Symposium 35

Tuesday, September 11, 9:55-11:25 Room B-2

Dysregulation of Protein Homeostasis (Proteostasis): Novel Mechanism in Alcohol Use Disorders and Organ Injury

Organizer / Chair:
Pranoti Mandrekar Dept of Medicine, University of Massachusetts Medical School, USA
Chair:
Andras Orosz Div of Metabolism and Health Effects, NIAAA, NIH, USA
SY35-1
CELL-TO-CELL VARIABLE MOLECULAR RESPONSES FOR MAINTENANCE OF PROTEOSTASIS EPIGENETICALLY PROGRAM LIFE-LONG PATHOLOGICAL CONDITIONS IN FASD
Kazue Hashimoto-Torii
Children's National Medical Center, USA
SY35-2
INHIBITING NLRP3 INFLAMMASOME AND IL-1BETA IN ALCOHOLIC LIVER DISEASE VIA THERAPEUTIC TARGETING OF THE PROTEOSTASIS CHAPERONE
Pranoti Mandrekar
Dept. of Medicine, University of Massachusetts Medical School, USA
SY35-3
COLLAGEN-SPECIFIC MOLECULAR CHAPERONE HSP47 WOULD BE A THERAPEUTIC TARGET FOR FIBROTIC DISEASES
Shinya Ito
Institute for Protein Dynamics, Kyoto Sangyo University, Japan
SY35-4
ETHANOL-INDUCED DISORGANIZATION OF GOLGI APPARATUS AND ALTERED PROTEIN TRAFFICKING: ROLE OF DEFECTIVE RAB3D FUNCTION
Carol A. Casey
Department of Internal Medicine, University of Nebraska Medical Center and Omaha VAMC, USA

Symposium 36

Tuesday, September 11, 14:55-16:25 Room B-2

Alcohol and Organ Damage: Bridging the Gap Between Bench and Bedside - Part 2: Bench

Organizer / Chair:
Kenichi Ikejima Department of Gastroenterology, Juntendo Univeristy Graduate School of Medicine, Japan
Chair:
Gavin E. Arteel Dept. of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, USA
SY36-1
THE ROLE OF ENDOPLASMIC RETICULUM STRESS ON ALCOHOLIC LIVER INJURY IN A MURINE MODEL OF CHRONIC-BINGE ETHANOL FEEDING
Maiko Suzuki
Juntendo Univeristy Graduate School of Medicine, Japan
SY36-2
LYSOSOMAL BIOGENESIS AND ALCOHOLIC PANCREATITIS
Wen-xing Ding
Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, USA
SY36-3
MACROPHAGE INHIBITORY FACTOR (MIF) ATTENUATES HEPATIC STEATOSIS, BUT PROMOTES HEPATIC CARCINOGENESIS
Norio Horiguchi
Gunma University of Medicine, Internal Medicine of Gastroenterology and Hepatology, Japan
SY36-4
TRANSITIONAL CHANGES TO THE MATRISOME AND ALCOHOLIC LIVER DISEASE, MORE THAN COLLAGEN AND FIBROSIS
Gavin E. Arteel
Dept. of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, USA

Symposium 37

Tuesday, September 11, 9:55-11:25 Room K

Young Investigator's Symposium in Asia 1

Organizer / Chair:
Sung-gon Kim Psychiatry, Pusan National University, Korea
SY37-1
RATE OF BLACKOUT AND ITS NEGATIVE CONSEQUENCES IN UNIVERSITY STUDENTS
Kyeong-Mi Kang
Busan Community Addiction Management Center, Korea
SY37-2
PREDICTIVE FACTORS FOR TREATMENT FAILURE IN REDUCING ALCOHOLIC CONSUMPTION BY CASE MANAGEMENT FOR ALCOHOLICS LIVING IN PERMANENT RENTAL APARTMENTS
Myung-hee Song
Psychiatric Nurse / Department of Busan Cmmunity Addiction Management Center, Pusan National University Hospital, Korea
SY37-3
CHANGES IN THE DRINKING BEHAVIOR OF KOREAN WOMEN DURING THE PREVIOUS 20 YEARS
Bi A Seo
Pusan National University Yangsan Hospital, Korea
SY37-4
SENSIBLE AND NATURAL ALCOHOLISM PREVENTION PROGRAM FOR YOU (SNAPPY), A SUITE OF WEB-BASED SCREENING AND BRIEF INTERVENTION TOOLS FOR EXCESSIVE ALCOHOL CONSUMPTION
Takashi Sunami
Saga-ken Medical Centre Koseikan, Japan

Symposium 38

Tuesday, September 11, 14:55-16:25 Room K

The Current Situation and Treatment Systems for Drug Addiction in Asia

Organizer / Chair:
Tomohiro Shirasak Department of Psychiatry, Teine Keijinkai Hospital, Japan
Chair:
Toshikazu Saito Psychiatry Institute, Hokujinkai Medical Corporation, Japan
SY38-1
DRUG ABUSE IN MALAYSIA
Anne Yee
University Malaya, Malaysia
SY38-2
TREATMENT SYSTEM OF DRUG ADDICTION IN TAIWAN: MOVING FORWARD ON A WANDERING JOURNEY
Chia Chun Hung
Bali Psychiatric Center, Ministry of Health and Welfare, Taiwan
SY38-3
TREATMENT SYSTEM FOR DRUG ADDICTION IN INDONESIA: CHALLENGING SYSTEM FOR DEVELOPING COUNTRY
Kristiana Siste Kurniasanti
Department of Psychiatry, University of Indonesia, Indonesia
SY38-4
CONSIDERATIONS ON THE PRESENT TREATMENT SYSTEMS AND ISSUES OF DRUG ADDICTION IN JAPAN
Moritoshi Kido
Osaka University of Commerce, Japan

Symposium 39

Tuesday, September 11, 16:30-18:00 Room K

Leaning from the Differences Regarding the Relationship Between Social Structures and Substances Use

Organizer / Chair:
Masuo Tanaka Koryo Hosipital, Japan
Chair:
Tetsuji Cho Department of Psychiatry, Mental Care Center, Prefecture of Mie, Japan
SY39-1
CHANGES IN TREATMENT FOR ALCOHOL USE DISORDER IN JAPAN
Tetsuji Cho
Department of Psychiatry, Mental Care Center, Mie, Japan
SY39-2
DIFFERENT CHARACTERISTICS OF AUD BETWEEN THE US AND JAPAN
Hiroshi Sakuma
Saigata Medical Center, Japan
SY39-3
CURRENT SITUATION ON SUBSTANCE USE DISORDERS IN BOSNIA AND HERZEGOVINA
Visnja Banjac
Clinic of Psychiatry, University Clinical Center of the Republic of Srpska, Bosnia and Herzegovina
SY39-4
IRELAND'S ALCOHOL PROBLEM: A PUBLIC HEALTH ISSUE
Leo Yoshida
National Suicide Research Foundation, Ireland

Symposium 40

Tuesday, September 11, 9:55-11:25 Room C-1

Binge Drinking: From Risk to Consequences

Organizer / Chair:
John Crabbe Department of Behavioral Neuroscience, Oregon Health & Science University, USA
SY40-1
BEHAVIORAL FACTORS PREDICTING THE RISK OR RESILIENCE TO CONSUME ALCOHOL AND LOSE CONTROL OVER ALCOHOL SEEKING IN RATS
Heidi Lesscher
Department of Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Netherlands
SY40-2
A ROLE FOR PHOSPHODIESTERASE TYPE 4 (PDE4) IN BINGE-LIKE DRINKING
Angela R. Ozburn
Oregon Health & Science University, USA
SY40-3
MATERNAL ALCOHOL BINGE DRINKING INDUCES MOLECULAR ALTERATIONS IN THE BRAIN AND BEHAVIORAL DYSFUNCTIONS IN OFFSPRING MICE
Lídia Cantacorps
Neurobiology of Behavior Research Group (GReNeC-NeuroBio), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Spain
SY40-4
ASSOCIATION BETWEEN EXCESSIVE ALCOHOL USE AND ALCOHOL-RELATED INJURIES - A MULTICENTER CROSS SECTIONAL STUDY OF COLLEGE STUDENTS IN JAPAN
Kyoko Kawaida
Nursing Faculty of National Defense Medical College, Japan

Symposium 41

Tuesday, September 11, 14:55-16:25 Room C-1

Novel Technologies and Integrated Approaches for Obtaining and Using Real-time Alcohol Consumption Data Collected in Naturalistic Environments

Organizer / Chair:
Susan E. Luczak University of Southern California, USA
Chair:
Vijay A. Ramchandani National Institute on Alcohol Abuse and Alcoholism, USA
INTRODUCTION TO THE SYMPOSIUM:
Katherine Jung Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, USA
SY41-1
A NOVEL POPULATION-BASED MODEL APPROACH TO ESTIMATING BREATH ALCOHOL CONCENTRATION (BRAC) FROM TRANSDERMAL ALCOHOL CONCENTRATION (TAC) BIOSENSOR DATA
Susan E. Luczak
University of Southern California, USA
SY41-2
USING EMA AND SENSOR DATA TO UNDERSTAND THE RELATIONSHIPS BETWEEN DRINKING AND EMOTIONAL STATES AMONG PERSONS LIVING WITH HIV (PLWH)
Yan Wang
University of Florida, USA
SY41-3
ALTERNATE REPRESENTATIONS OF SUBJECTIVE EFFECTS: AN ECOLOGICAL STUDY OF SIMULTANEOUS ALCOHOL AND MARIJUANA USE
Kristina M. Jackson
Brown University, USA
SY41-4
TESTING THE EFFICACY OF THE MOBILE INTERVENTION FOR DRINKING IN YOUNG PEOPLE (MIDY): AN ECOLOGICAL MOMENTARY INTERVENTION TO REDUCE YOUNG ADULTS ALCOHOL USE IN THE EVENT
Cassandra J. Wright
Burnet Institute, Australia
DISCUSSANT:
Kenneth J. Sher Department of Psychological Sciences, University of Missouri, USA

Symposium 42

Tuesday, September 11, 16:30-18:00 Room C-1

The Fact and Issue of Alcohol Use Among Asian Adolescences - For the Purpose of Future Collaboration on Youth Risk Behaviour Monitoring

Organizer / Chair:
Yoneatsu Osaki Division of Environmental and Preventive Medicine, Department of Social Medicine, Faculty of Medicine, Tottori University, Japan
SY42-1
ALCOHOL AND DRUGS ABUSE AMONG ADOLESCENT IN INDONESIA
Kristiana Siste Kurniasanti
Department of Psychiatry, University of Indonesia, Indonesia
SY42-2
ALCOHOL USE AMONG ADOLESCENTS IN KOREA
Sungwon Roh
Department of Psychiatry, Hanyang University College of Medicine, Korea
SY42-3
PREVALENCE, CHARACTERISTICS, AND FACTORS ASSOCIATED WITH ALCOHOL USE AMONG ADOLESCENTS IN THAILAND: A REVIEW OF PUBLISHED DATA
Wanlop Atsariyasing
Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
SY42-4
THE FACTS AND ISSUES OF ALCOHOL USE AMONG ADOLESCENTS AND YOUTH IN JAPAN
Aya Kinjo
Division of Environmental and Preventive Medicine, Department of Social Medicine, Faculty of Medicine, Tottori University, Japan

Symposium 43

Tuesday, September 11, 9:55-11:25 Room C-2

Update of Alcohol Dependence/Alcohol Use Disorder and Their Treatment in US, EU, and Japan
Co-sponsored by Otsuka Pharmaceutical Co., Ltd.

Chair:
Toshikazu Saito Psychiatry Institute, Hokujinkai Medical Corporation, Japan
SY43-1
CURRENT SITUATION AND FUTURE TASKS FOR THE TREATMENT OF ALCOHOL DEPENDENCE IN JAPAN
Susumu Higuchi
National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY43-2
TRENDS IN THE TREATMENT OF ALCOHOL DEPENDENCE IN THE EU
Jonathan Chick
Edinburgh Napier University and Castle Craig Hospital, UK
SY43-3
THE CURRENT STATUS OF ALCOHOL USE DISORDER AND ITS TREATMENT IN THE U.S.
Robert M. Swift
Brown University Center for Alcohol and Addiction Studies, USA

Symposium 44

Tuesday, September 11, 14:55-16:25 Room C-2

Alcohol Misuse Effects on Brain Structure from Adolescence to Senescence: In Vivo MRI, Indices for Identifying At-risk Youth, Postmortem Brain-Bank Material for Validating in Vivo Findings and Enabling Genetic Investigations

Organizer / Chair:
Edith V. Sullivan Psychiatry, Stanford University School of Medicine, USA
Chair:
Adolf Pfefferbaum SRI International, Menlo Park, California, USA
SY44-1
LONGITUDINAL STUDIES OF ALCOHOLISM-RELATED BRAIN STRUCTURAL CHANGES FROM ADOLESCENCE TO SENESCENCE
Adolf Pfefferbaum
SRI International, Menlo Park, California, USA
SY44-2
LEVEL OF RESPONSE TO ALCOHOL MEASURED ON THE SELF-RATING OF THE EFFECTS OF ALCOHOL QUESTIONNAIRE IN KOREAN MEDICAL STUDENTS
Alfreda Stadlin
College of Medicine, Ajman University, United Arab Emirates
SY44-3
USING HUMAN POST-MORTEM BRAIN TISSUE TO ADVANCE THE UNDERSTANDING OF ALCOHOL-RELATED BRAIN DAMAGE
Jillian J. Kril
Sydney Medical School, University of Sydney, Australia
SY44-4
COMBINING GWAS AND TRANSCRIPTOME DATA TO DEFINE GENES AND PATHWAYS IN ALCOHOLISM
R. Dayne Mayfield
Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, USA

Symposium 45

Tuesday, September 11, 16:30-18:00 Room C-2

New Perspectives in the Pharmacotherapy of Alcohol Dependence

Organizer / Chair:
Karl F. Mann Central Institute of Mental Health, University of Heidelberg, Germany
Chair:
Susumu Higuchi National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY45-1
A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, 3-PARALLEL-GROUP COMPARISON TRIAL TO INVESTIGATE THE EFFECT OF NALMEFENE ON ALCOHOL CONSUMPTION REDUCTION IN PATIENTS WITH ALCOHOL DEPENDENCE IN JAPAN
Susumu Higuchi
National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY45-2
CAN WE LIMIT TENDENCY OF DOCTORS TO INAPPROPRIATE DIAGNOSIS AND PHARMACOTHERAPY IN ALCOHOL AND SUBSTANCE MISUSING PATIENTS?
Jonathan Chick
Edinburgh Napier University and Castle Craig Hospital, UK
SY45-3
REDUCED DRINKING FOR ALCOHOL DEPENDENT PATIENTS, WHAT IS THE EVIDENCE IN PHARMACOTHERAPY TRIALS?
Karl F. Mann
Central Institute of Mental Health, University of Heidelberg, Germany
SY45-4
ALTERNATIVE ENDPOINTS IN ALCOHOL CLINICAL TRIALS: THE WORLD HEALTH ORGANIZATION DRINKING RISK LEVELS
Katie Witkiewitz
University of New Mexico, USA
DISCUSSANT:
Stephanie S. O'Malley Yale School of Medicine, USA

Symposium 46

Wednesday, September 12, 9:55-11:25 Room A

Understanding Neural Circuits Underlying Natural and Ethanol Reward

Organizer / Chair:
Igor Ponomarev Waggoner Center for Alcohol & Addiction Research and the College of Pharmacy, The University of Texas at Austin, USA
SY46-1
MECHANISMS ENCODING SEXUAL AND ETHANOL REWARD WITHIN THE DROSOPHILA NERVOUS SYSTEM
Galit Shohat-Ophir
The Faculty of Life Sciences and The Multidisciplinary Brain Research Center, Bar Ilan University, Israel
SY46-2
CIRCUITS AND MOLECULES DRIVING CUE-INDUCED ALCOHOL PREFERENCE
Emily Petruccelli
Department of Neuroscience, Brown University, USA
SY46-3
LASTING EFFECTS OF INCREASING NUCLEUS ACCUMBENS ACTIVITY ON BINGE-LIKE ALCOHOL DRINKING AND THE TRANSCRIPTOME
Angela R. Ozburn
Oregon Health & Science University, USA
SY46-4
THE EFFECTS OF THE PDE4 INHIBITOR APREMILAST ON CELLULAR PHYSIOLOGY AND ETHANOL DRINKING
Regina A. Mangieri
The University of Texas at Austin, USA

Symposium 47

Wednesday, September 12, 14:55-16:25 Room A

A New Era of Alcoholism Research for Unveiling Neural, Cognitive, and Genetic Dysfunctions; From Basic to Bedside

Organizer / Chair:
Shigenobu Toda Department of Psychiatry, Showa University School of Medicine, Japan
Chair:
Ming Chyi Huang Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taiwan
SY47-1
HOW IS A HABIT DEVELOPED OR UNDEVELOPED?: IMPLICATIONS FOR A CRITICAL ROLE OF ATTENTION DURING A GOAL-DIRECTED PROCESS OF OPERANT LEARNING IN RATS
Shigenobu Toda
Department of Psychiatry, Showa University School of Medicine, Japan
SY47-2
HOW SOCIAL DEPRIVATION DIFFERENTIALLY AFFECTS ALCOHOL INTAKE BEHAVIOR AMONG MALE AND FEMALE MICE?
Yuki Moriya
Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan
SY47-3
IDENTIFICATION OF GENETIC POLYMORPHISMS ASSOCIATED WITH HUMAN SENSITIVITY TO ADDICTIVE SUBSTANCES AND ITS CLINICAL APPLICATION
Daisuke Nishizawa
Department of Psychiatry and Behavioral Science (Addictive Substance Project), Tokyo Metropolitan Institute of Medical Science, Japan
SY47-4
A REPORT OF THE FUNCTIONAL MRI STUDY WITH SEVERE ALCOHOL USE DISORDER (AUD) PATIENTS
Shou Fukushima
Department of Neuropsychiatry, Nagasaki University, Nagasaki, Japan

Symposium 48

Wednesday, September 12, 16:30-18:00 Room A

WHO-ISBRA Symposium: Advances in Alcohol Research and Alcohol Policy Developments

Organizer:
Susumu Higuchi National Hospital Organization Kurihama Medical and Addiction Center, Japan
Chair:
Vladimir Poznyak Management of Substance Abuse, World Health Organization, Switzerland
SY48-1
EFFECTIVE POLICY MEASURES TO REDUCE ALCOHOL-RELATED HARM: AN UPDATE OF THE BOOK, "ALCOHOL: NO ORDINARY COMMODITY"
Thomas F. Babor
Department of Community Medicine, University of Connecticut School of Medicine, USA
SY48-2
MOVING BEYOND THE GREAT EXCEPTION: THE GLOBAL CHALLENGE OF REGULATING ALCOHOL
Robin Room
Centre for Alcohol Policy Research, La Trobe University, Melbourne, Australia
SY48-3
MEASURING AND PREVENTING ALCOHOL USE AND RELATED HARM AMONG YOUNG PEOPLE IN ASIAN COUNTRIES: A THEMATIC REVIEW
Xiao J. Xiang
Second Xiangya Hospital of Central South University, China
SY48-4
THE CHANGES IN ALCOHOL CONSUMPTION EPIDEMIOLOGY AND MARKETING, AND ITS IMPLICATION IN ALCOHOL POLICY IN KOREA
Hae Kook Lee
Department of Psychiatry, The Catholic University of Korea, Seoul, Korea

Symposium 49

Wednesday, September 12, 9:55-11:25 Room B-1

Genetic Studies on the Development and Consequences of Alcohol Use Disorders

Organizer / Chair:
Sachio Matsushita National Hospital Organization Kurihama Medical and Addiction Center, Japan
Chair:
Akitoyo Hishimoto Department of Psychiatry, Kobe University Graduate School of Medicine, Japan
SY49-1
THE ROLE OF SYSTEM xCT IN ADDICTION
Wei-Ling Chen
Chiayi & Wanqiao Branch, Taichung Veterans General Hospital, Taiwan
SY49-2
ALCOHOL-RELATED POLYMORPHISMS AND RISK FOR SUICIDE IN THE JAPANESE POPULATION
Ikuo Otsuka
Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
SY49-3
PERCEIVED RESPONSE TO ALCOHOL AS A PHENOTYPE FOR RISK OF ALCOHOL RELATED PROBLEMS IN YOUNG JAPANESE ADULTS
Sachio Matsushita
National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY49-4
ABERRANT TELOMERES IN ALCOHOL DEPENDENCE, MOOD DISORDER AND SUICIDE
Naruhisa Yamaki
Department of Psychiatry, Kobe University Graduate School of Medicine, Japan

Symposium 50

Wednesday, September 12, 14:55-16:25 Room B-1

The Role of Glycinergic Mechanisms for Ethanol's Mechanism of Action and for Controlling Alcohol Intake

Organizer / Chair:
Bo Soderpalm Institute of Neuroscience and Physiology, University of Gothenburg, Sweden
Chair:
Luis Aguayo Department of Physiology, University of Concepcion, Chile
SY50-1
ROLE OF ALPHA1 AND ALPHA2 SUBUNITS IN ETHANOL MEDIATED POTENTIATION OF GLYCINE RECEPTORS IN NUCLEUS ACCUMBENS
Luis Aguayo
Department of Physiology, University of Concepcion, Chile
SY50-2
ROLE OF TAURINE FOR ETHANOL´S INTERACTION WITH GLYCINE RECEPTORS CONTROLLING DOPAMINE IN THE NUCLEUS ACCUMBENS
Mia Ericson
Institute of Neuroscience and Physiology, University of Gothenburg, Sweden
SY50-3
CHRONIC INTERMITTENT VOLUNTARY ALCOHOL ADMINISTRATION ELEVATES GLYCINE SIGNALS IN THE LATERAL HABENULA OF RATS
Jiang H. Ye
Anesthesiology, Rutgers, the State University of New Jersey, USA
SY50-4
A HUMAN LABORATORY TRIAL ASSESSING HIGH-DOSE GLYCINE FOR REDUCING ALCOHOL CRAVING IN ALCOHOL DEPENDENT SUBJECTS
Helga Lidö
Institute of Neuroscience and Physiology, University of Gothenburg, Sweden

Symposium 51

Wednesday, September 12, 16:30-18:00 Room B-1

HIV and Alcohol Co-morbidities: Pathogenesis and Treatment

Organizers / Chairs:
Natalia A. Osna University of Nebraska Medical Center, USA
Patricia E. Molina Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center, USA
SY51-1
ALCOHOL-SIV/HIV-ART INTERACTIONS & METABOLIC COMORBIDITY PATHWAYS
Patricia E. Molina
Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center, USA
SY51-2
ALCOHOL POTENTIATES HIV-INDUCED EXTRACELLULAR VESICLES (EV) RELEASE: CONTRIBUTION TO LIVER INFLAMMATION AND FIBROSIS
Natalia A. Osna
University of Nebraska Medical Center, USA
SY51-3
ALCOHOL AND HIV-INFECTION INDUCED EPIGENETIC HISTONE MODIFICATIONS IMPAIR CD4+ T LYMPHOCYTE GENE EXPRESSION: RELEVANCE TO HIV-1 PATHOGENESIS
Shirish Barve
Department of Medicine, University of Louisville, USA
SY51-4
NEUROPATHOLOGICAL MECHANISMS OF ALCOHOL, SIV, AND ANTIRETROVIRAL THERAPY: ENHANCED SUSCEPTIBILITY OF THE FRONTAL CORTEX IN RHESUS MACAQUES
Scott Edwards
Alcohol & Drug Abuse Center of Excellence, Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, USA
SY51-5
TRIAL OF ZINC SUPPLEMENTATION TO IMPROVE MARKERS OF MORTALITY AND HIV DISEASE PROGRESSION IN HIV-POSITIVE DRINKERS IN RUSSIA
Elena Blokhina
Pavlov First State Medical University, Russia

Symposium 52

Wednesday, September 12, 9:55-11:25 Room B-2

Translational Research on the Neurodevelopmental Effects of Prenatal Alcohol Exposure and Treatment Strategies for Fetal Alcohol Spectrum Disorders

Organizer / Chair:
Jeffrey R. Wozniak University of Minnesota, USA
Chair:
Jennifer D. Thomas Center for Behavioral Teratology, San Diego State University, USA
SY52-1
EVALUATING THE EFFECTIVENESS OF MINOCYCLINE TREATMENT FOLLOWING PRENATAL ALCOHOL EXPOSURE: IMPACTS ON BEHAVIOUR AND IMMUNE FUNCTION
Tamara S. Bodnar
The University of British Columbia, Canada
SY52-2
THYROID FUNCTION IN PREGNANT WOMEN WITH MODERATE TO SEVERE ALCOHOL CONSUMPTION IS RELATED TO INFANT DEVELOPMENTAL OUTCOMES
Kirsty A. Donald
University of Cape Town, South Africa
SY52-3
CHOLINE ALTERS HIPPOCAMPAL DEVELOPMENT: IMPLICATIONS FOR THE TREATMENT OF FETAL ALCOHOL SPECTRUM DISORDERS
Jennifer Thomas
Center for Behavioral Teratology, San Diego State University, USA
SY52-4
CHOLINE AS A NEURODEVELOPMENTAL INTERVENTION FOR CHILDREN WITH FETAL ALCOHOL SPECTRUM DISORDERS
Jeffrey R. Wozniak
University of Minnesota, USA

Symposium 53

Wednesday, September 12, 14:55-16:25 Room B-2

Alcohol-induced Organ Damages

Organizer / Chair:
Toshikazu Saito Psychiatry Institute, Hokujinkai Medical Corporation, Japan
Chair:
Sebastian Mueller Salem Medical Center and Center for Alcohol Research, University of Heidelberg, Germany
SY53-1
DYSFUNCTION OF AUTOPHAGY IS INVOLVED IN THE PROGRESSION OF ALCOHOLIC AND NON-ALCOHOLIC FATTY LIVER DISEASES
Shunhei Yamashina
Department of Gastroenterology, Juntendo University School of Medicine, Japan
SY53-2
ALCOHOL-RELATED IRON OVERLOAD: ROLE OF NOX4 IN HEPATIC IRON SIGNALING
Ines Silva
Center for Alcohol Research, University of Heidelberg and Salem Medical Center, Heidelberg, Germany
SY53-3
MASKED HEMOLYSIS AS IMPORTANT FACTOR OF IRON OVERLOAD IN ALD
Vanessa Rausch
Center for Alcohol Research, University Hospital Heidelberg and Salem Medical Center, Germany
SY53-4
ALCOHOLIC LIVER INJURY: CLINICAL ASPECTS IN RELATION TO PATHOGENESIS AND HEPATOCARCINOGENESIS
Makiko Taniai
Department of Internal Medicine and Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan

Symposium 54

Wednesday, September 12, 16:30-18:00 Room B-2

Alcohol Use Disorders and Comorbid Conditions

Organizer / Chair:
Ismene L. Petrakis Department of Psychiatry, Yale University School of Medicine, USA
SY54-1
ALCOHOL USE DISORDER AND CO-MORBID SMOKING: EARLY PREDICTORS OF END OF TREATMENT SMOKING AND DRINKING IN A TRIAL OF VARENICLINE TARTRATE
Stephanie S. O'Malley
Yale School of Medicine, USA
SY54-2
SUPPORTIVE TEXT MESSAGES FOR PATIENTS WITH ALCOHOL USE DISORDER AND COMORBID DEPRESSION. SIX MONTH RANDOMISED CONTROLLED TRIAL WITH AFTERCARE
Conor K. Farren
Department of Psychiatry, Trinity College Dublin, Ireland
SY54-3
PHARMACOLOGIC TREATMENT OF AUD AND COMORBID POSTTRAUMATIC STRESS DISORDER (PTSD): IMPACT OF PTSD ON TREATMENT OUTCOMES
Ismene L. Petrakis
Department of Psychiatry, Yale University School of Medicine, USA
SY54-4
IMPACT OF PSYCHIATRIC COMORBIDITY ON TREATMENT OUTCOME FOR INPATIENTS WITH ALCOHOL DEPENDENCE
Yosuke Yumoto
National Hospital Organization Kurihama Medical and Addiction Center, Japan

Symposium 55

Wednesday, September 12, 9:55-11:25 Room K

The Current Situation and Treatment Systems for Alcoholics in Pacific Countries

Organizer / Chair:
Tomohiro Shirasaka Department of Psychiatry, TeineKeijinkai Hospital, Japan
Chair:
Hisatsugu Miyata Department of Psychiatry, Jikei University School of Medicine, Japan
SY55-1
THE CURRENT SITUATION AND TREATMENT SYSTEMS FOR ALCOHOLISM IN KOREA
Euihyeon Na
Addiction Treatment Center, Department of Psychiatry, Maeumsarang Hospital, Korea
SY55-2
SURVEY OF THE RELATIONSHIP BETWEEN ALCOHOL-RELATED COGNITIVE DYSFUNCTION AND CEREBRAL BLOOD FLOW
Tomohiro Shirasaka
Department of Psychiatry, Teine Keijinkai Hospital, Japan
SY55-3
DETECTION OF ALCOHOL USE DISORDER IN A GENERAL HOSPITAL
Woraphat Ratta-Apha
Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
SY55-4
THE USE OF GABAERGIC SUBSTANCES IN BUPRENORPHINE MAINTENANCE TREATMENT
Tae Woo Park
Department of Psychiatry, Boston University School of Medicine, USA

Symposium 56

Wednesday, September 12, 14:55-16:25 Room K

Young Investigator's Symposium in Asia 2

Organizer:
Sung-gon Kim Psychiatry, Pusan National University, Korea
Chair:
Woo-young Jung Department of Psychiatry, Pusan National University Yangsan Hospital, Korea
SY56-1
THE CHARACTERISTICS OF ALCOHOLICS VISITING A COMMUNITY COUNSELING CENTER
Eun Jeong Min
Psychiatry, Pusan National University Yangsan Hospital, Korea
SY56-2
A STUDY ON SELECTION FACTORS OF HOSPITALS BEFORE HOSPITALIZATION OF KOREAN ALCOHOL-DEPENDENT PATIENTS
Na-yeong Byeon
Psychiatry Social Worker, Busan Community Addiction Management Center, Pusan National University Hospital, Korea
SY56-3
EFFECTS OF EXPERIENCING THE TEMPLE STAY PROGRAM ON DRINKING BEHAVIOR IN KOREAN ALCOHOL-DEPENDENT PATIENTS
Jung-soo Lee
S.W / Department of Busan Community Addiction Management Center, Pusan National University Hospital, Korea
SY56-4
SURVEY FINDINGS ON THE CIRCUMSTANCES AND ATTITUDES OF CHUGGING AMONG JAPANESE YOUNG ADULTS
Hiroaki Itoh
National Hospital Organization Kurihama Medical and Addiction Center, Japan

Symposium 57

Wednesday, September 12, 16:30-18:00 Room K

Emerging Issues on Addiction in Indonesia

Organizer / Chair:
Kristiana Siste Kurniasanti
  Department of Psychiatry, University of Indonesia, Indonesia
SY57-1
PRESCRIPTION DRUGS ABUSE IN INDONESIA: NEW PHENOMENON, HOW TO HANDLE?
Daniella Satyasari
Residents in Psychiatry Department, University of Indonesia/Cipto Mangunkusumo Hospital, Indonesia
SY57-2
SMARTPHONE ADDICTION AMONG YOUNG PEOPLE: IS IT REAL IN INDONESIA?
Enjeline Hanafi
Department of Psychiatry, University of Indonesia, Indonesia
SY57-3
NATIONAL TREATMENT PROGRAM TO MANAGE EMERGING ISSUES ON ADDICTION
Iman Firmansyah
National Narcotic Board, Indonesia
SY57-4
ADDICTION MODULE FOR UNDERGRADUATE STUDENTS SCHOOL OF MEDICINE ATMA JAYA CATHOLIC UNIVERSITY OF INDONESIA
Eva Suryani Lie
Department Mental Health and Behavior, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Indonesia

Symposium 58

Wednesday, September 12, 9:55-11:25 Room C-1

How Should We Promote a Strategy for Healthy Drinking?

Organizer / Chair:
Koshi Nakamura Department of Public Health, Hokkaido University Faculty of Medicine, Japan
Chair:
Kohji Takada Department of Psychology, Teikyo University, Japan
SY58-1
ALCOHOL USE IN ASIA AND PUBLIC HEALTH APPROACHES FOR REDUCING ALCOHOL-RELATED HARM IN JAPAN
Aya Kinjo
Division of Environmental and Preventive Medicine, Department of Social Medicine, Faculty of Medicine, Tottori University, Japan
SY58-2
THE USE OF ALCOHOL MIXED WITH CAFFEINATED BEVERAGES IN TAIWANESE MANUAL WORKERS
Wan-ju Cheng
Department of Psychiatry, China Medical University Hospital, Taiwan
SY58-3
SAFETY/HEALTHY DRINKING PROGRAM: HOW DOES IT WORK IN THE THAI CONTEXT?
Wachiraporn Arunothong
Department of Psychiatry, Lampang Regional Hospital, Lampang, Thailand
SY58-4
ESTABLISHING ALCOHOL CESSATION PROGRAM IN MALAYSIA SETTING: INTEGRATING PSYCHODYNAMIC CONSTRUCTS IN THE MODULE
Hazli Zakaria
The National University of Malaysia, Malaysia

Symposium 59

Wednesday, September 12, 14:55-16:25 Room C-1

Disasters and Addictive Behaviors

Organizer / Chair:
Sachio Matsushita National Hospital Organization Kurihama Medical and Addiction Center, Japan
Chair:
Kristiana Siste Kurniasanti Department of Psychiatry, University of Indonesia, Indonesia
SY59-1
CANNABIS ABUSE IN TEEN SURVIVORS WHO LOST SIGNIFICANT FIGURES IN EARTHQUAKE AND TSUNAMI1
Syahrial B. Marwan Iskandar
University of Indonesia, Indonesia
SY59-2
ALCOHOL-RELATED PROBLEMS IN FUKUSHIMA: MULTIDIMENSIONAL EFFECTS CAUSED BY THE NUCLEAR DISASTER
Masaharu Maeda1
Department of Disaster Psychiatry, Fukushima Medical University, Japan,
SY59-3
ALCOHOL USE, MENTAL HEALTH AND PHYSICAL HEALTH STATUS IN BEREAVED FAMILIES OF THE SEWOL FERRY DISASTER IN KOREA
Ji-ae Yun
Department of Psychiatry, Eulji University Hospital, Korea
SY59-4
THE IMPACT OF THE GREAT EAST JAPAN EARTHQUAKE ON ALCOHOL AND HYPNOTIC USE AND GAMBLING BEHAVIORS IN DISASTER-STRICKEN AREAS
Sachio Matsushita
National Hospital Organization Kurihama Medical and Addiction Center, Japan

Symposium 60

Wednesday, September 12, 9:55-11:25 Room C-2

The e:Med Consortium Uses a Systems Medicine Approach to Predict for Alcohol Use Disorders Trajectories, Treatment Responses and Mode of Action for New Anti-craving Drugs

Organizer / Chair:
Rainer Spanagel Central Institute for Mental Health, Germany
Chair:
Hamid R. Noori Max Planck Institute for Biological Cybernetics, Germany
SY60-1
DEFINING INDIVIDUAL RISK PROFILES IN ADOLESCENTS THAT ARE PREDICTIVE OF ALCOHOL USE DISORDERS LATER IN LIFE
Sylvane Desrivières
King's College London, UK
SY60-2
DEFINING RISK AND RESILIENCE FACTORS FOR THE COURSE OF ALCOHOL USE DISORDERS
Katrin Charlet
National Institute on Alcohol Abuse and Alcoholism (NIAAA) / National Institutes of Health (NIH), USA
SY60-3
PREDICTING DISEASE TRAJECTORIES AND TREATMENT RESPONSE IN RATS WITH BASELINE ACTIVITY AND DRINKING DATA
Rainer Spanagel
Central Institute for Mental Health, Germany
SY60-4
PREDICTING NEUROCHEMICAL RESPONSES AND MECHANISMS OF PUTATIVE ANTI-CRAVING DRUGS
Hamid Noori
Max Planck Institute for Biological Cybernetics, Germany

Symposium 61

Wednesday, September 12, 14:55-16:25 Room C-2

ISBRA Young Investigator Award Symposium

Chair:
Marissa Roberto, Ph.D. Member of the ISBRA Board of Directors and Education Committee
Oral Presentations:
YIA-1
CRITICAL ROLE FOR THE ANTERIOR INSULAR CORTEX IN THE PROPENSITY TO RELAPSE FOLLOWING PUNISHMENT-IMPOSED ABSTINENCE TO ALCOHOL SEEKING
Erin J. Campbell
The Florey Institute of Neuroscience and Mental Health, Australia
YIA-2
CIRCUITS AND MOLECULES DRIVING CUE-INDUCED ALCOHOL PREFERENCE
Emily Petruccelli
Department of Neuroscience, Brown University, USA
YIA-3
RISK FACTORS FOR LONG-TERM PRESCRIPTION OF BENZODIAZEPINE: COHORT STUDY USING A LARGE HEALTH INSURANCE CLAIM DATABASE IN JAPAN
Ayumi Takano
Department of Psychiatric Nursing, Yokohama City University, Japan
Poster Presentations:
YIA-4
NICOTINE INCREASES ALCOHOL SELF-ADMINISTRATION VIA MU OPIOID RECEPTOR ACTIVITY IN THE VENTRAL TEGMENTAL AREA
Esi Domi
Center for Social and Affective Neuroscience, IKE, Linkoping University, Linkoping, 581 83, Sweden
YIA-5
EARLY POSTNATAL ETHANOL EXPOSURE AFFECTS MIDLINE THALAMUS AND BEHAVIORS DEPENDENT ON PREFRONTAL-THALAMO-HIPPOCAMPAL CIRCUIT IN ADULT RAT
Zachary H. Gursky
Department of Psychological & Brain Sciences, University of Delaware, USA

Symposium 62

Thursday, September 13, 9:00-10:30 Room A

Ventral Hippocampus Circuits and Alcoholismrelated Behavior

Organizer / Chair:
Jacqueline M. Barker Department of Pharmacology and Physiology, Drexel University, USA
Chair:
William C. Griffin Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, USA
SY62-1
THE ROLE OF THE VENTRAL HIPPOCAMPUS IN APPROACH-AVOIDANCE CONFLICT RESOLUTION - RELEVANCE TO ADDICTION
Rutsuko Ito
Department of Psychology, University of Toronto Scarborough, Canada
SY62-2
THE ROLE OF THE VENTRAL HIPPOCAMPAL TO ACCUMBENS PATHWAY ON ETHANOL DRINKING IN ETHANOL DEPENDENT AND NON-DEPENDENT MICE
William C. Griffin
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, USA
SY62-3
REGULATION OF BEHAVIORAL FLEXIBILITY BY VENTRAL HIPPOCAMPUS PROJECTIONS
Jacqueline M. Barker
Department of Pharmacology and Physiology, Drexel University, USA
SY62-4
THE VENTRAL HIPPOCAMPUS MAY REPRESENT A NEXUS FOR MALADAPTIVE SYNAPTIC ALTERATIONS ASSOCIATED WITH ALCOHOL USE DISORDER AND COMORBID ANXIETY DISORDERS
Jeff L. Weiner
Department of Physiology and Pharmacology, Wake Forest School of Medicine, USA

Symposium 63

Thursday, September 13, 10:50-12:20 Room A

Modulation of Reward Mechanisms by Alcohol

Organizer / Chair:
Esa R. Korpi Department of Pharmacology, University of Helsinki, Finland
Chair:
Elisabet Jerlhag Holm Department of Pharmacology, University of Gothenburg, Sweden
SY63-1
EXPLOITING BRAIN DOPAMINE (DA) SYSTEMS FOR DEVELOPMENT OF NEW TREATMENT MODALITIES FOR ALCOHOL USE DISORDER (AUD)
Bo Söderpalm
University of Gothenburg, Sweden
SY63-2
MODULATION OF VTA NEUROPLASTICITY AND REWARDING BEHAVIORS OF ETHANOL BY GABA-B RECEPTOR PAMS
Esa R. Korpi
Department of Pharmacology, University of Helsinki, Finland
SY63-3
ETHANOL ACUTE EFFECTS ON THE STRIATAL GABAERGIC PROJECTIONS TO THE SUBSTANTIA NIGRA PARS RETICULADA AND THE GLOBUS PALLIDUS
Karina P. Abrahao
NIAAA/NIH, USA
SY63-4
GUT-BRAIN PEPTIDES AND ALCOHOL USE DISRORDERS: ROLE OF REWARD MECHANISMS
Elisabet Jerlhag
Department of Pharmacology, University of Gothenburg, Sweden

Symposium 64

Thursday, September 13, 9:00-10:30 Room B-1

Novel Mechanisms of Ethanol-induced Damage to the Developing Brain

Organizer / Chair:
Carlos F. Valenzuela Department of Neurosciences/ University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Chair:
Consuelo Guerri Research Center Principe Felipe, Cell Pathology Laboratory, Valencia, Spain
SY64-1
ALCOHOL-INDUCED MICROCEPHALY INVOLVES A REDUCTION IN RETINOIC ACID SIGNALING IN THE HEAD-INDUCING PRECHORDAL MESENDODERM
Abraham Fainsod
Dept. of Developmental Biology and Cancer Research, Faculty of Medicine, Hebrew University of Jerusalem, Israel
SY64-2
ROLE OF THE TLR4 IMMUNE RESPONSE IN ALCOHOLINDUCED BRAIN DYSFUNCTIONS IN A MODEL OF FETAL ALCOHOL SPECTRUM DISORDERS (FASD)
Maria Pascual
Department of Molecular and Cellular Pathology of Alcohol, Principe Felipe Research Center, Valencia, Spain
SY64-3
EXPOSURE OF MICE TO ETHANOL DURING THE THIRD TRIMESTER-EQUIVALENT PERIOD DAMAGES HIPPOCAMPAL INTERNEURONS
Carlos F. Valenzuela
Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
SY64-4
PRENATAL ALCOHOL EXPOSURE ALTERS WHITE MATTER MICROSTRUCTURE IN NEONATES AND 2 YEAR OLDS
Kirsten A. Donald
University of Cape Town, South Africa
DISCUSSANT:
Edward Riley San Diego State University, USA

Symposium 65

Thursday, September 13, 10:50-12:20 Room B-1

Adolescent Alcohol Abuse: Risks, Mechanisms of Pathology and Consequences

Organizer / Chair:
Fulton T. Crews Director of The Bowles Center for Alcohol Studies, UNC - Chapel Hill, USA
SY65-1
ADOLESCENT INTERMITTENT ALCOHOL EXPOSURE ENHANCES SENSITIVITY TO FUTURE STRESS EVENTS THAT PROMOTE ABNORMAL FEAR-RELATED BEHAVIOR IN ADULTHOOD
Lawrence J. Chandler
Department of Neuroscience, Medical University of South Carolina, USA
SY65-2
ALCOHOL BINGEING IN YOUNG ADULTS IS ASSOCIATED WITH ALTERED BRAIN REGIONAL FMRI RESPONSES TO ATTENTIONAL, DECISION MAKING AND EMOTIONAL CHALLENGES; PREDISPOSING FACTORS
Theodora Duka
School of Psychology, University of Sussex, UK
SY65-3
BINGE-LIKE ETHANOL TREATMENT IN ADOLESCENCE IMPAIRS AUTOPHAGY AND HINDERS SYNAPTIC MATURATION: ROLE OF THE NEUROIMMUNE ACTIVATION
Consuelo Guerri
Research Center Principe Felipe, Cell Pathology Laboratory, Valencia, Spain
SY65-4
NEUROIMMUNE ACTIVATION BY ADOLESCENT ALCOHOL EXPOSURE AND IN HUMAN ALCOHOLIC BRAIN
Fulton T. Crews
Director of The Bowles Center for Alcohol Studies, UNC – Chapel Hill, USA
DISCUSSANT:
Dai Stephens Department of Psychology, University of Sussex, UK

Symposium 66

Thursday, September 13, 9:00-10:30 Room B-2

Epigenetic Mechanisms of Alcohol Toxicity

Organizer:
A Leslie Morrow Bowles Center for Alcohol Studies, UNC School of Medicine, USA
Chair:
Rajesh Miranda Texas A&M University, USA
SY66-1
MICRORNA BIOMARKERS AND MEDIATORS OF PRENATAL ALCOHOL EFFECTS
Rajesh C. Miranda
Texas A&M University, USA
SY66-2
HDACS MEDIATE ETHANOL MECHANISMS OF ETHANOL DEPENDENCE INVOLVING GABA-A RECEPTOR FUNCTION AND EXPRESSION
A Leslie Morrow
Bowles Center for Alcohol Studies, UNC School of Medicine, USA
SY66-3
MOLECULAR BIOMARKERS OF GENE EXPRESSION AND EPIGENETIC MIRNAS IN AUD
Nicolas Ramoz
INSERM U894, Center of Psychiatry and Neuroscience, France
SY66-4
DIFFERENTIAL METHYLATION OF ALDH2 GENE PROMOTER IN PATIENTS WITH AUD
Hansi Pathak
Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Germany

Symposium 67

Thursday, September 13, 10:50-12:20 Room B-2

Mechanisms, Biomarkers and Targets for Therapy in Alcohol-associated Liver Injury: From Genetics to Nutrition

Organizer / Chair:
Irina A. Kirpich Department of Medicine, University of Louisville, USA
Chair:
Kusum Kharbanda University of Nebraska Medical Center; VA Medical Center, USA
SY67-1
PLASMA RESOLVIN D1 LEVELS ARE REDUCED IN ALCOHOLIC HEPATITIS: A POSSIBLE MECHANISM OF AND POTENTIAL THERAPY FOR ALCOHOLIC LIVER DISEASE
Irina Kirpich
Department of Medicine, University of Louisville, USA
SY67-2
DEFECTIVE METHYLATION REACTIONS PROMOTE THE PATHOGENESIS OF ALCOHOLIC LIVER INJURY: PREVENTION BY BETAINE ADMINISTRATION
Kusum K. Kharbanda
University of Nebraska Medical Center, USA
SY67-3
PANETH CELL DYSFUNCTION MEDIATES ALCOHOL-INDUCED DYSBIOSIS AND HEPATITIS IN MICE: ROLE OF ZINC DEFICIENCY
Zhanxiang Zhou
Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, NC 28081, USA
SY67-4
RELEVANCE OF GENETICS IN ALCOHOLIC LIVER DISEASE (ALD)
Devanshi Seth
Royal Prince Alfred Hospital and Centenary Institute, Australia
SY67-5
BIOMARKERS FOR ALCOHOLIC HEPATITIS: IMPLICATIONS FOR DIAGNOSIS AND THERAPY
Shirish Barve
University of Louisville, USA

Symposium 68

Thursday, September 13, 9:00-10:30 Room K

Recent Studies on Alcohol Use Disorders in Japan and Korea

Organizer:
Sung-gon Kim Psychiatry, Pusan National University, Korea
Chair:
Kyeseong Lee Incheon ChamSarang Hospital, Korea
SY68-1
CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE IV GENE POLYMORPHISMS IN KOREAN ALCOHOL-DEPENDENT PATIENTS
Woo-young Jung
Department of Psychiatry, Pusan National University Yangsan Hospital, Korea
SY68-2
PREDICTING FACTORS OF LONG-TERM FOLLOW-UP IN TREATING ALCOHOLICS WITH NALTREXONE OR ACAMPROSATE IN KOREA
Sung Young Huh
Department of Psychiatry, Pusan National University Yangsan Hospital, Korea
SY68-3
DIFFERENCE OF EXECUTIVE DYSFUNCTION BETWEEN ALCOHOL DEPENDENCE &SCHIZOPHRENIA IN COMPARISON WITH TRAUMATIC BRAIN INJURY AND NORMALCONTROL SUBJECT
Kyeseong Lee
Incheon ChamSarang Hospital, Korea
SY68-4
THE EFFECTS OF BRIEF INTERVENTION AT A WORK PLACE
Hitoshi Maesato
National Hospital Organization Kurihama Medical and Addiction Center, Japan

Symposium 69

Thursday, September 13, 10:50-12:20 Room K

Recent Clinical Studies on Genetic Polymorphisms of Ethanol-metabolizing Enzymes in Japan and Korea

Organizer:
Sung-gon Kim Psychiatry, Pusan National University, Korea
Chair:
Sachio Matsushita National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY69-1
AN ASSOCIATION STUDY ABOUT ALCOHOL METABOLISM AND ITS EFFECTS ON COGNITION AND SUBJECTIVE ALCOHOL EFFECT IN POPULATIONS WITH DIFFERENT ALDH2 GENOTYPES
Sung-gon Kim
Psychiatry, Pusan National University, Korea
SY69-2
SLOW-METABOLIZING ADH1B AND INACTIVE HETEROZYGOUS ALDH2 INCREASE VULNERABILITY TO FATTY LIVER AND DECREASE VULNERABILITY TO CIRRHOSIS IN JAPANESE MEN WITH ALCOHOL DEPENDENCE
Akira Yokoyama
National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY69-3
IDENTIFICATION OF RISK FACTORS FOR ALCOHOL DEPENDENCE USING THE AIA MODEL: COMORBID PSYCHIATRIC AND PERSONALITY DISORDERS
Mitsuru Itoh
National Hospital Organization Kurihama Medical and Addiction Center, Japan
SY69-4
INFLUENCE OF GENETIC VARIATION IN ETHANOL-METABOLIZING ENZYMES ON ALCOHOL USE AND DIAGNOSIS OF ALCOHOL DEPENDENCE AMONG JAPANESE MALE ALCOHOLICS
Tomoko Yonemoto
National Hospital Organization Kurihama Medical and Addiction Center, Japan

Symposium 70

Thursday, September 13, 10:50-12:20 Room C-1

Methamphetamine Epidemic in the Philippines and Countermeasures to Overcome Problems

Organizer / Chair:
Takayuki Harada University of Tsukuba, Japan
Chair:
Ivanhoe Escartin Department of Health, Philippines
SY70-1
PROJECT FOR INTRODUCING EVIDENCE-BASED RELAPSE PREVENTION PROGRAM TO DRUG DEPENDENCE TREATMENT AND REHABILITATION CENTERS IN THE PHILIPPINES
Ivanhoe Escartin
Department of Health, Philippines
SY70-2
DETERMINANTS OF RELAPSE RISKS AMONG DRUG USERS PARTICIPATING IN TREATMENT PROGRAMS AT RESIDENTIAL FACILITIES AND COMMUNITIES IN THE PHILIPPINES
Shogo Kanamori
Japan International Cooperation Agency, Japan
SY70-3
ASSESSING THE SEVERITY OF DEPENDENCE AMONG DRUG USERS PARTICIPATING IN TREATMENT PROGRAMS AT RESIDENTIAL FACILITIES AND COMMUNITIES IN THE PHILIPPINES
Alfonso Villaroman
Department of Health, Philippines
SY70-4
RECOVERY CLINICS AND RECOVERY HOMES: RAPID DEVELOPMENT OF A PUBLIC-SECTOR, COMMUNITY-BASED, FULLY VOLUNTARY MEDICAL TREATMENT MODEL OF ADDICTION CARE IN THE PHILIPPINES
Peter Banys
European Union - EPOS, Philippines

Symposium 71

Thursday, September 13, 9:00-10:30 Room C-2

Allosteric Modulator Drugs As Potential Treatments for Alcohol Use Disorders

Organizer / Chair:
Robert M. Swift Brown University Center for Alcohol and Addiction Studies, USA
Chair:
Carolina Haass-Koffler Brown University, USA
SY71-1
DESIGN, SYNTHESIS AND CHARACTERIZATION OF SMALL MOLECULE GROUP II METABOTROPIC GLUTAMATE RECEPTOR ALLOSTERIC MODULATORS
Nicholas Cosford
Sanford Burnham Prebys Medical Discovery Institute, USA
SY71-2
DEVELOPMENT OF CORTICOTROPIN RELEASING FACTOR BINDING PROTEIN ALLOSTERIC MODULATORS
Carolina L. Haass-Koffler
Brown University, USA
SY71-3
LONGITUDINAL NEUROIMAGING OF MGLU5 DURING ALCOHOL ABSTINENCE
Ansel Hillmer
Dept. of Psychiatry, Yale University, USA
SY71-4
EFFECT OF THE MGLUR5 MODULATOR GET 73 ON ALCOHOL PHARMACOKINETICS AND PHARMACODYNAMICS AND ALCOHOL CRAVING IN A HUMAN LABORATORY MODEL
Robert M. Swift
Brown University Center for Alcohol and Addiction Studies, USA

Symposium 72

Thursday, September 13, 10:50-12:20 Room C-2

New Insights on the Neurobiology of Alcoholism: A Step Forward for Medication Development

Organizer / Chair:
Roberto Ciccocioppo University of Camerino, Italy
Chair:
Koji Teshima Mitsubishi Tanabe Pharma Corporation, Japan
SY72-1
ALCOHOL DEPENDENCE AND WITHDRAWAL DYSREGULATE THE AMYGDALAR GABAERGIC SYNAPSES
Marisa Roberto
Department of Neuroscience, The Scripps Research Institute, USA
SY72-2
STIMULI CONDITIONED TO ALCOHOL CONSUMPTION DURING WITHDRAWAL PRODUCE COMPULSIVE-LIKE BEHAVIOR IN TESTS OF ALCOHOL SEEKING AS MEASURED BY RESISTANCE TO PUNISHMENT AND TOLERANCE OF INCREASED WORKLOAD
Friedbert Weiss
The Scripps Research Institute, USA
SY72-3
NOCICEPTIN RECEPTOR ANTAGONISM DECREASES ALCOHOL DRINKING AND SEEKING IN MALE AND FEMALE MARCHIGIAN SARDINIAN ALCOHOL-PREFERRING (MSP) RATS
Roberto Ciccocioppo
University of Camerino, Italy
SY72-4
ML375 A NOVEL NEGATIVE ALLOSTERIC MODULATOR (NAM) OF (M5) MUSCARINIC RECEPTOR (MACHR) ATTENUATES ALCOHOL DRINKING AND SEEKING IN GENETICALLY SELECTED IP RATS THROUGH MODULATION OF DORSOLATERAL STRIATUM M5 RECEPTORS
Andrew J. Lawrence
Florey Institute of Neuroscience & Mental Health, Australia

Page Top

ISBRA-WHO Workshop

ISBRA-WHO Workshop 1

Sunday, September 9, 13:30-15:00 Room B-1

Defining and Diagnosing Disorders Due to Substance Use and Addictive Behaviours: Focus on ICD-11 and Its Comparisons With ICD-10 and Dsm-5

Facilitator:
Vladimir Poznyak Management of Substance Abuse,World Health Organization, Switzerland

The workshop will focus on innovations in nomenclature and classification of disorders due to alcohol and other substance use and addictive behaviours in the 11th revision of International Classification of Diseases (ICD-11) release by the World Health Organization (WHO) in June 2018. The introductory presentation made by WHO staff (Dr V. Poznyak) will be followed by critical assessments of classification of mental and behavioural disorders (Dr W. Kosmowski, Poland) and disorders due to addictive behaviours (Dr K. Sisite, Indonesia) in ICD-11. A significant part of the workshop will be devoted to questions and answers and open discussion about advantages and limitations of the current international classification systems.

WS1-1
CLINICAL ASPECTS OF TAXONOMY OF SUBSTANCE USE DISORDERS: BETWEEN SEMANTICS AND LOGIC, ICD-11 AND ITS COMPARISON WITH ICD-10 AND DSM-5
Wojciech E. Kosmowski
Department of Psychiatry CM Bydgoszcz, Nicolaus Copernicus University, Poland
WS1-2
GAMBLING AND GAMING DISORDER AS ADDICTION BEHAVIOR IN ICD-11 AND DSM-5: SIMILARITIES AND DIFFERENCES
Kristiana Siste Kurniasanti
Psychiatry, Universitas Indonesia, Indonesia

ISBRA-WHO Workshop 2

Sunday, September 9, 15:30-17:00 Room B-1

Alcohol and Drug Epidemiology to Inform Policy Development: How to Conduct Relevant Epidemiological Research on Substance Use and Substance Use Disorders

Facilitator:
Hans Jurgen Rumpf University of Lubeck, Department of Psychiatry and Psychotherapy, Germany

In general, epidemiological studies investigate distributions and determinants of health conditions. These investigations can be related to whole populations or specific subgroups. Epidemiology in the field of alcohol and drugs serves a number of purposes. Prevalence estimations and respective trends are needed to inform health professionals and policy makers of areas that need special attention. Analytical epidemiology enables to find risk factors and resilience mechanisms. This kind of information can be used for prevention and treatment. In addition, epidemiological data can inform on needs for specific services, e.g. in health care. In this workshop, two junior scientists present their work from different areas and by using different methodological approaches. One study comes from Nepal and investigates profiles of alcohol dependent patients submitted to a deaddiction ward. The second presentation is on a large-scale investigation using data from a Chinese biobank. In this investigation, the risk of different cancers in relation to alcohol consumption will be presented. Participants of the workshop will have the opportunity to highlight strengths of the papers and to develop suggestions for future projects. In addition, basic information on methods related to the two examples will be presented.

WS2-1
PROFILE OF ALCOHOL-DEPENDENT PATIENTS ADMITTED IN DEADDICTION WARD OF A TERTIARY LEVEL HOSPITAL IN NEPAL
Sagun B. Pant
Department of Psychiatry and Mental Health, Institute of Medicine, Tribhuvan University Teaching Hospital, Nepal
WS2-2
ALCOHOL DRINKING AND RISK OF CANCERS: FINDINGS FROM THE CHINA KADOORIE BIOBANK
Pek Kei Im
Nuffield Department of Population Health, University of Oxford, UK

ISBRA-WHO Workshop 3

Monday, September 10, 9:50-11:20 Room B-1

Reliable and Accurate Brief Assessment of Alcohol Use and Alcohol Use Disorders in Health Care Settings

Facilitator:
John B. Saunders Centre for Youth Substance Abuse Research, University of Queensland, Australia

In this workshop approaches to undertaking accurate assessment of alcohol use disorders in various settings will be examined. In his introduction Dr. John Saunders (Australia) will canvass the many health care settings where these disorders may be identified and the use of the AUDIT questionnaire to do so. The purpose and nature of the assessment will differ in these settings, as will the nature of the intervention. Dr. Woraphat Ratta-Apha (Thailand) will present on screening for unhealthy alcohol use in general hospital patients. Dr. Tomohiro Shirasaka (Japan) will describe the approach in Japan to assess alcohol use disorders in patients with comorbid mental health disorders and early intervention for alcohol use disorders. Dr. Stephanie Baggio (Switzerland) will report on the use of the DSM-5 criteria to assess alcohol use disorder and notes a high false-positive rate with the recommended cut-off threshold of two features. Dr. Satti Sitanggang (Indonesia) reports on the problems associated with illegal alcohol consumption in Indonesia and the need for a concise assessment tool (and brief intervention) particularly directed at those consuming alcohol occasionally and who are particularly likely to consume products with toxic additives.

WS3-1
ASSESSMENT OF ALCOHOL USE DISORDERS IN DIFFERENT HEALTH CARE SETTINGS
John B. Saunders
Centre for Youth Substance Abuse Research, University of Queensland, Australia
WS3-2
SCREENING FOR UNHEALTHY ALCOHOL USE IN GENERAL HOSPITAL PATIENTS
Woraphat Ratta-Apha
Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
WS3-3
ASSESSING ALCOHOL USE IN PATIENTS WITH COMORBID MENTAL HEALTH DISORDERS IN JAPAN: EARLY INTERVENTION OF ALCOHOLISM FROM THE GENERAL HOSPITAL IN JAPAN
Tomohiro Shirasaka
Department of Psychiatry, Teine Keijinkai Hospital, Sapporo, Japan
WS3-4
SELF-REPORTED DSM-5 ELEVEN CRITERIA TO ASSESS ALCOHOL USE DISORDER: IS IT A RELIABLE AND ACCURATE BRIEF ASSESSMENT? EVIDENCE FROM A COMMUNITY-BASED SAMPLE
Stéphanie Baggio
Geneva University Hospitals, Switzerland
WS3-5
DEATH CAUSED BY 'OPLOSAN' (HIGH CONCENTRATION AND MIXED FORMULA) ALCOHOL IN INDONESIA
Satti R. Sitanggang
Psychiatric Division of Pambalah Batung General Hospital, Indonesia

ISBRA-WHO Workshop 4

Monday, September 10, 13:00-14:30 Room B-1

Translating Evidence into Practice in Different Health Care Systems: Focus on Brief Interventions and Cognitive Behavioural Therapies in the Management of Alcohol Use and Alcohol Use Disorders

Facilitators:
Michie N. Hesselbrock Department of Psychiatry, University of Connecticut School of Medicine, USA
Victor M. Hesselbrock Department of Psychiatry, University of Connecticut School of Medicine, USA

While the evidence for prevention of alcohol misuse and treatment of alcohol use disorders continues to grow, there remain significant delays in translating effective strategies into health care practice settings throughout the world. It is important for the research field to be aware of current evidence, to build upon it, but it is also crucial for investigators to be aware of gaps in implementation and increase knowledge and action regarding closing those gaps. This session will include both a review of the literature on the current state of translating research on treatment of alcohol use disorders and prevention of at-risk drinking into practice, and an interactive discussion of ideas for research questions that will lead to improvements in health service delivery.

Two presentations will highlight current issues in research translation. The first will show how an approach using a mindfulness-based cognitive behavioral intervention was implemented in health treatment settings in the U.S. and whether it was effective in preventing relapse. This is a significant research question, as relapse is a persistent problem during recovery from alcohol use disorder. The second will present data from a study of an aromadiagnostic approach for identifying mood issues in women in treatment for alcohol dependence and alcohol withdrawal syndrome in a psychiatric/narcologic hospital in Uzbekistan. Aromatherapy and aromadiognistic approaches are used in parts of Russia, Kazakhstan, Uzbekistan, and many parts of Asia. Their adoption by the medical establishment in North America and Western Europe is beginning to grow and will depend upon more research on effectiveness and best implementation strategies.

WS4-1
MINDFULNESS-BASED RELAPSE PREVENTION FOR ALCOHOL USE DISORDER: A NOVEL APPROACH FOR TREATMENT IN DIVERSE HEALTH CARE SETTINGS
Katie Witkiewitz
University of New Mexico, USA
WS4-2
AROMATHERAPY IN THE COMPLEX TREATMENT OF EMOTIONAL DISORDERS IN THE STRUCTURE OF ALCOHOL ABSTINENCE SYNDROME
Azizbek A. Ismatov
Department of Psychiatry and Narcology, Tashkent Medical Academy, Uzbekistan

ISBRA-WHO Workshop 5

Monday, September 10, 14:50-16:20 Room B-1

How to Increase Treatment Coverage for Alcohol Use Disorders

Facilitator:
Karl F. Mann Central Institute of Mental Health, University of Heidelberg, Germany

Treatment for Alcohol Use Disorders (AUD) works reasonably well. However, too few people get engaged into treatment for different reasons. This phenomenon has been called "treatment gap" and was shown in independent studies around the world to be in the order of 80 to 90%. In other works, only 10 to 20% of individuals in need are really being treated. In the introductory presentation it shall be outlined what reasons might be driving the gap and what can be done about it. Several attempts have shown promise such as the motivational strategies, systematic involvement of relatives and harm reduction strategies. One approach has gained new momentum through the initiative of the European Medicines Agency (EMA). Snice 2010 they accept intermediate treatment goals such as the reduction of drinking without having to follow a strict abstinence orientation from the beginning. A number of analyses show that even alcohol dependent patients can reduce their consumption over time with benefits in terms of improved biomarkers, morbidity and quality of life.
The introduction will be followed by two presentations from participants of the workshop and an intense discussion with all people taking part in the workshop.

WS5-1
TREATMENT OF PATIENTS WITH MULTIPLE SUBSTANCE USE DISORDERS
Mirjana Delic
Center for Treatment of Drug Addiction, University Psychiatric Hospital Ljubljana, Slovenia
WS5-2
HOW TO INCREASE TREATMENT COVERAGE FOR ALCOHOL DEPENDENT PATIENTS - SPECIAL POPULATIONS IN POLAND
Michal J. Turczynowicz-Kosmowski
Faculty of Law, University of Warsaw, Poland

ISBRA-WHO Workshop 6

Monday, September 10, 16:30-18:00 Room B-1

How to Prepare an Effective Scientific Papers and Conference Presentations

Facilitator:
Michie N. Hesselbrock Department of Psychiatry, University of Connecticut School of Medicine, USA

This will be a master technical workshop for investigators who are interested in improving their skills preparing PowerPoint slide presentations at professional meetings and in advancing their technical skills in preparing manuscripts for publication in scientific journals. The workshop will focus heavily on newer investigators (including post-docs) and non-native English speaking investigators.
The major objective of the proposed workshop will be to provide a 'hands on' experience for clinicians and researchers who have knowledge of basic and clinical research methodologies and who are interested in developing more advanced skills in the public dissemination of their scientific work.
The session will include interactive lectures by journal editors and senior investigators focusing on skill building in preparing both PowerPoint presentations and scientific manuscripts as well as interactive question and answer opportunities between senior investigators/editors and the participants. Participants will be asked to bring research ideas and barriers they have encountered when preparing manuscripts and presentations.

The agenda includes:
• Preparing effective presentations
• Description of the peer review process and the journal editor's role
• Advice from current journal editors
• Common problems encountered by new and non-English speaking authors

Senior Investigators

Marc Schuckit, MD
University of California, San Diego, USA
Kathy Bucholz, PhD
Washington University, St. Louis, USA
Victor Hesselbrock, PhD
University of Connecticut, USA
Michie Hesselbrock, PhD
University of Connecticut, USA

Acknowledgment: Funding for this conference was made possible (in part) by grants R13AA022578 and R13AA020691 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA).

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The 13th International Symposium on ALPD and Cirrhosis

Sunday, September 9, Room C-2

Organizers:
Michio Imawari, Yoshiyuki Takei, Sam Zakhari, Bin Gao, Hide Tsukamoto

*Keynote speakers: 30 min talk plus 5min Q&A
Others: 20 min talk plus 5 min Q&A;
Young investigators: 10 min talk plus 5 min Q&A

13:15-13:30
Opening remarks

Hide Tsukamoto/Kathy Jung

Session-1: Gut Dysbiosis and Alcoholic Liver Disease (ALD)

Moderators:
Michio Imawari and Hide Tsukamoto
13:30-14:05
Akkermansia muciniphila and alcoholic liver disease

*Herbert Tilg

14:05-14:30
Gut dysbiosis, nuclear transglutaminase and hepatocyte death

Soichi Kojima

14:30-14:55
Circadian clock and dysbiosis in ALD

Ali Keshavarzian

Break (15min)

15:10-15:45
The roles and mechanisms of cellular senescence in obesity-associated liver cancer

*Eiji Hara

15:45-16:20
Gut dysbiosis and alconolic liver disease (ALD)

*Bernd Schnabl

16:20-17:00
Two young investigators selected from submitted abstracts

Monday, September 10 Room C-2

Session-2: Alcohol, Inflammation and Organ Crosstalk

Moderators:
Kenichi Ikejima and Bin Gao
8:30-8:55
Sterile inflammation in ASH and NASH

Wajahat Zafar Mehal

8:55-9:20
Alcohol, inflammation, and organ cross-talk

Laura Nagy

9:20-9:45
Alcohol-induced liver-lung interactions

Gavin Arteel

9:45-10:10
Proteostasis: an important regulator of inflammation in ALD

Pranoti Mandrekar

Break (15min)

10:25-10:50
IL-17 links liver inflammation to alcohol dependence

Tatiana Kisseleva

10:50-11:15
ROS generation via endocytosis of TLR4-NOX2 in macrophages

Won-Il Jeong

11:15-11:40
Extracelluar vesicle miRNAs in alcoholic steatohepatitis

Akiko Eguchi

11:40-12:05
Role of autophagy in alcohol-induced adipose atrophy and liver injury

Wen-Xing Ding

Session-3: Alcohol, Metabolic Reprogramming, and Malignancies

Moderators:
Helmut Seitz and Makiko Taniai
13:15-13:40
Cell fate and metabolic reprogramming of tumor-initiating stem-like cells

Keigo Machida

13:40-14:05
Hepatic steatosis and impaired glucose homeostasis

Won Kim

14:05-14:30
Lipidomic abnormalities in ASH

Puneet Puri

14:30-14:55
Role of cytoglobin in stellate cell activation, liver fibrosis, and cancer development

Norifumi Kawada

Break (15min)

15:10-15:45
Treatment of liver fibrosis and cirrhosis

*David Brenner

15:45-16:10
microRNA in alcohol induced liver injury

Li Wang

16:10-16:35
Promotion of pancreatic cancer development by alcohol and Western diet feeding

Kinji Asahina

16:35-17:05
Two selected young investigators from submitted abstracts
17:05-17:15
The 14th (2020) ALPD symposium announcement

Dong Joon Kim

17:15-17:20
Closing Remarks

Yoshiyuki Takei